Nasser Nooh1, Dana T Graves. 1. College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Abstract
BACKGROUND: Oral wound healing is reported to occur more rapidly than dermal healing due, in part, to factors in saliva that facilitate the repair process. However, the oral environment also presents challenges to healing that include a large commensal flora and trauma from mastication. METHODS: Excisional punch biopsies (1.5 mm) were placed in the scalp and hard palate of mice to create similar wounds with an osseous floor and relatively thick connective tissue walls. Histomorphometric analysis of hematoxylin and eosin-stained sections was performed at the widest part of each lesion. RESULTS: The rate of epithelial and connective tissue coverage and the amount of new connective tissue formed were delayed in the oral compared to dermal wounds. In addition, the number of polymorphonuclear leukocytes (PMNs) was significantly higher and more persistent in the oral wounds. CONCLUSIONS: Under conditions where a considerable amount of new connective tissue synthesis is required, oral healing is slower than dermal repair. This may be due to a higher degree of inflammatory stimulation induced by conditions present in the oral environment.
BACKGROUND: Oral wound healing is reported to occur more rapidly than dermal healing due, in part, to factors in saliva that facilitate the repair process. However, the oral environment also presents challenges to healing that include a large commensal flora and trauma from mastication. METHODS: Excisional punch biopsies (1.5 mm) were placed in the scalp and hard palate of mice to create similar wounds with an osseous floor and relatively thick connective tissue walls. Histomorphometric analysis of hematoxylin and eosin-stained sections was performed at the widest part of each lesion. RESULTS: The rate of epithelial and connective tissue coverage and the amount of new connective tissue formed were delayed in the oral compared to dermal wounds. In addition, the number of polymorphonuclear leukocytes (PMNs) was significantly higher and more persistent in the oral wounds. CONCLUSIONS: Under conditions where a considerable amount of new connective tissue synthesis is required, oral healing is slower than dermal repair. This may be due to a higher degree of inflammatory stimulation induced by conditions present in the oral environment.
Authors: M F Siqueira; J Li; L Chehab; T Desta; T Chino; N Krothpali; Y Behl; M Alikhani; J Yang; C Braasch; D T Graves Journal: Diabetologia Date: 2009-11-10 Impact factor: 10.122
Authors: Kyungho Lee; Heithem Ben Amara; Sang Cheon Lee; Richard Leesungbok; Min Ah Chung; Ki-Tae Koo; Suk Won Lee Journal: Tissue Eng Regen Med Date: 2019-11-21 Impact factor: 4.169