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Literature DB >> 12666122

Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia.

Roger L Albin¹, Donna Cross, Wayne T Cornblath, John A Wald, Kristine Wernette, Kirk A Frey, Satoshi Minoshima.

Abstract

Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.

Entities: Chemical Disease

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Year: 2003 PMID： 12666122 DOI： 10.1002/ana.10527

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

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Cited

10 in total

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Journal: J Med Chem Date: 2013-07-18 Impact factor: 7.446

2. Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia.

Authors: Morvarid Karimi; Stephen M Moerlein; Tom O Videen; Yi Su; Hubert P Flores; Joel S Perlmutter
Journal: Mov Disord Date: 2013-10-21 Impact factor: 10.338

3. Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.

Authors: Karin Mente; Nancy A Edwards; Demelio Urbano; Abhik Ray-Chaudhury; Diego Iacono; Ana Tereza Di Lorenzo Alho; Eduardo Joaquim Lopes Alho; Edson Amaro; Silvina G Horovitz; Mark Hallett
Journal: Mov Disord Date: 2018-03-06 Impact factor: 10.338

4. Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter.

Authors: Prashanth K Padakanti; Xiang Zhang; Junfeng Li; Stanley M Parsons; Joel S Perlmutter; Zhude Tu
Journal: Mol Imaging Biol Date: 2014-12 Impact factor: 3.488

5. Positron emission tomography imaging of (2R,3R)-5-[(18)F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter.

Authors: Michael R Kilbourn; Brian Hockley; Lihsueh Lee; Phillip Sherman; Carole Quesada; Kirk A Frey; Robert A Koeppe
Journal: Nucl Med Biol Date: 2009-05-08 Impact factor: 2.408

6. Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons.

Authors: Samuel S Pappas; Katherine Darr; Sandra M Holley; Carlos Cepeda; Omar S Mabrouk; Jenny-Marie T Wong; Tessa M LeWitt; Reema Paudel; Henry Houlden; Robert T Kennedy; Michael S Levine; William T Dauer
Journal: Elife Date: 2015-06-08 Impact factor: 8.140

Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia.

1. Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter.

2. Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia.

3. Pedunculopontine Nucleus Cholinergic Deficiency in Cervical Dystonia.

4. Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter.

5. Positron emission tomography imaging of (2R,3R)-5-[(18)F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter.

6. Forebrain deletion of the dystonia protein torsinA causes dystonic-like movements and loss of striatal cholinergic neurons.

7. A cell autonomous torsinA requirement for cholinergic neuron survival and motor control.

Review 8. Convergent evidence for abnormal striatal synaptic plasticity in dystonia.

9. Striatal Cholinergic Interneurons in a Knock-in Mouse Model of L-DOPA-Responsive Dystonia.

10. Vesicular Acetylcholine Transporter Alters Cholinergic Tone and Synaptic Plasticity in DYT1 Dystonia.