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Literature DB >> 1266578

Damage of skeletal muscle in rats by immunoglobulins. I. Pathophysiological data and lightmicroscopic observations.

Abstract

An experimental model of the autoimmune process was developed to study the pathophysiological and structural changes in immunomyopathies. Immune-sera derived from three muscle proteins--myofibril, myosin and actin--produced immunomyopathies for study. The pathophysiological data show that the general muscle efficiency began to decrease with the early stages of treatment and reflected a severe disorder to muscle function with the progression of time. Parallel changes were also observed by light microscopy.

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Year: 1976 PMID： 1266578 DOI： 10.1007/BF00688675

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

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References

23 in total

6. The skeletal muscle binding site of antistriated muscle antibody in myasthenia gravis: an electron microscopic immunohistochemical study using peroxidase conjugated antibody fragments.

Authors: J R Mendell; J N Whitaker; W K Engel
Journal: J Immunol Date: 1973-09 Impact factor: 5.422

7. Further studies on the specificity of presumed immune associations of myasthenia gravis and consideration of possible pathogenic implications.

Authors: A J Strauss; C W Smith; G W Cage; H W van der Geld; D E McFarlin; M Barlow
Journal: Ann N Y Acad Sci Date: 1966-01-26 Impact factor: 5.691

Damage of skeletal muscle in rats by immunoglobulins. I. Pathophysiological data and lightmicroscopic observations.

1. [The effect of regular muscle activity on the functioning of the adrenal cortex].

2. Experimental production of muscular dystrophy-like lesions in rabbits and guinea-pigs by an antoimmune process.

3. The bound nucleotide of the isolated myofibril.

4. Muscle lesions in mice injected with isologous and homologous muscle extracts.

5. Determination of serum proteins by means of the biuret reaction.

6. The skeletal muscle binding site of antistriated muscle antibody in myasthenia gravis: an electron microscopic immunohistochemical study using peroxidase conjugated antibody fragments.

7. Further studies on the specificity of presumed immune associations of myasthenia gravis and consideration of possible pathogenic implications.

Review 8. The genetic control of immunoglobulin synthesis.

9. Antimuscle factor and antinuclear factor in patients with myasthenia gravis. 1. Heavy chain determinants.

10. Thymic myoid cells and myasthenia gravis.