BACKGROUND: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. METHODS: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (>1,000 microg/mL) triclosan resistance in P aeruginosa was assessed. RESULTS: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1,000 microg/mL is solely attributable to the expression of efflux pumps.
BACKGROUND:Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. METHODS: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (>1,000 microg/mL) triclosan resistance in P aeruginosa was assessed. RESULTS: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1,000 microg/mL is solely attributable to the expression of efflux pumps.
Authors: F Heath Damron; Michael R Davis; T Ryan Withers; Robert K Ernst; Joanna B Goldberg; Guangli Yu; Hongwei D Yu Journal: Mol Microbiol Date: 2011-06-16 Impact factor: 3.501
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