Literature DB >> 12665204

Medium chain triglycerides as vehicle for palatable oral liquids.

Surendra M Bahal1, Jamie M Romansky, Francisco J Alvarez.   

Abstract

Aqueous liquid formulations of efavirenz, a nonnucleoside inhibitor of reverse transcriptase, have prolonged burning (peppery) taste. Medium-chain triglycerides (MCT) was used as the vehicle to mask the taste and obtain palatable oral liquid formulations containing 20 mg/mL efavirenz. The use of MCT for enhancement of palatability and stability is recommended for drugs that show high solubility and partitioning in this vehicle.

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Year:  2003        PMID： 12665204     DOI： 10.1081/pdt-120017518

Source DB:  PubMed          Journal:  Pharm Dev Technol        ISSN： 1083-7450            Impact factor:   3.133


  3 in total

1.  Physicochemical characterization of efavirenz-cyclodextrin inclusion complexes.

Authors:  Sateeshkumar Sathigari; Gurkishan Chadha; Y-H Phillip Lee; Nydeia Wright; Daniel L Parsons; Vijay K Rangari; Oladiran Fasina; R Jayachandra Babu
Journal:  AAPS PharmSciTech       Date:  2009-01-16       Impact factor: 3.246

Review 2.  Physical approaches to masking bitter taste: lessons from food and pharmaceuticals.

Authors:  John N Coupland; John E Hayes
Journal:  Pharm Res       Date:  2014-09-10       Impact factor: 4.200

3.  Efavirenz poisoning in a 12 year old HIV negative African boy.

Authors:  Rose Nazziwa; Moorine Sekadde; Francis Kanyike; Eric Wobudeya; Nicolette Nabukeera-Barungi
Journal:  Pan Afr Med J       Date:  2012-07-26
  3 in total

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