C W Nogueira1, E B Quinhones, E A C Jung, G Zeni, J B T Rocha. 1. Laboratório de Bioquímica Toxicológica, Departamento de Química, CCNE, Universidade Federal de Santa Maria, Santa Maria, RS, 97105-900, Brazil.
Abstract
OBJECTIVE AND DESIGN: Ebselen, an organoselenium compound is able to modulate the inflammatory response in rodents. In the present study, the anti-inflammatory and antinociceptive activity of diaryl diselenides and ebselen was studied. MATERIALS: Adult male Wistar rats and albino mice were treated with diaryl diselenides and ebselen in different doses. METHODS: Carrageenin-induced paw edema, tail-flick, formalin, acetic acid-induced abdominal writhing and capsaicin models of pain were carried out. Data were analyzed by ANOVA followed by Duncan's multiple range when appropriate. RESULTS: In all models, the most promising profile was displayed by diphenyl diselenide, which produced anti-inflammatory and antinociceptive activity significantly higher than ebselen. Diphenyl diselenide also produced dose-dependent antinociception when assessed in acetic acid-induced abdominal constriction, tail-flick test or formalin and capsaicin-induced nociception. CONCLUSION: The data presented here provide evidence that administration of diphenyl diselenide produced anti-inflammatory and antinociceptive activity.
OBJECTIVE AND DESIGN:Ebselen, an organoselenium compound is able to modulate the inflammatory response in rodents. In the present study, the anti-inflammatory and antinociceptive activity of diaryl diselenides and ebselen was studied. MATERIALS: Adult male Wistar rats and albino mice were treated with diaryl diselenides and ebselen in different doses. METHODS:Carrageenin-induced paw edema, tail-flick, formalin, acetic acid-induced abdominal writhing and capsaicin models of pain were carried out. Data were analyzed by ANOVA followed by Duncan's multiple range when appropriate. RESULTS: In all models, the most promising profile was displayed by diphenyl diselenide, which produced anti-inflammatory and antinociceptive activity significantly higher than ebselen. Diphenyl diselenide also produced dose-dependent antinociception when assessed in acetic acid-induced abdominal constriction, tail-flick test or formalin and capsaicin-induced nociception. CONCLUSION: The data presented here provide evidence that administration of diphenyl diselenide produced anti-inflammatory and antinociceptive activity.
Authors: Ana Cristina Guerra Souza; Eluza Curte Stangherlin; Ana Paula Ardais; Cristina Wayne Nogueira Journal: Mol Cell Biochem Date: 2010-02-24 Impact factor: 3.396
Authors: Maria Carla Medeiros; Amanda Mello; Tanise Gemelli; Cláudia Teixeira; Mariana de Almeida; Rodrigo B de Andrade; Clovis M D Wannmacher; Robson B Guerra; Rosane Gomez; Cláudia Funchal Journal: Neurochem Res Date: 2012-01-03 Impact factor: 3.996
Authors: César A Brüning; Marina Prigol; Cristiane Luchese; Cristiano R Jesse; Marta M M F Duarte; Silvane S Roman; Cristina W Nogueira Journal: Neurochem Res Date: 2012-07-31 Impact factor: 3.996
Authors: Roberta A Oliveira; Lucielli Savegnago; Cristiano R Jesse; Paulo H Menezes; Gary A Molander; Cristina W Nogueira Journal: Basic Clin Pharmacol Toxicol Date: 2009-03-27 Impact factor: 4.080