Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.

Literature DB >> 12663812

Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.

Alessandra Gradi¹, Yuri V Svitkin, Wolfgang Sommergruber, Hiroaki Imataka, Shigenobu Morino, Tim Skern, Nahum Sonenberg.

Abstract

Several picornaviruses shut down host cellular protein synthesis by proteolytic cleavage of the eukaryotic initiation factor (eIF) 4GI and eIF4GII isoforms. Viral RNA translation is maintained by a cap-independent mechanism. Here, we identify the human rhinovirus 2 2A(pro) cleavage site in eIF4GII in vitro as PLLNV(699)*GSR; this sequence lies seven amino acids C-terminal to the cleavage site previously identified in eIF4GI (LSTR681*GPP).

Entities: Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12663812 PMCID： PMC152112 DOI： 10.1128/jvi.77.8.5026-5029.2003

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

30 in total

1. Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.

Authors: J Marcotrigiano; A C Gingras; N Sonenberg; S K Burley
Journal: Cell Date: 1997-06-13 Impact factor: 41.582

2. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

Authors: F Rozen; I Edery; K Meerovitch; T E Dever; W C Merrick; N Sonenberg
Journal: Mol Cell Biol Date: 1990-03 Impact factor: 4.272

3. Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.

Authors: H Matsuo; H Li; A M McGuire; C M Fletcher; A C Gingras; N Sonenberg; G Wagner
Journal: Nat Struct Biol Date: 1997-09

4. Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

Authors: B J Lamphear; R Yan; F Yang; D Waters; H D Liebig; H Klump; E Kuechler; T Skern; R E Rhoads
Journal: J Biol Chem Date: 1993-09-15 Impact factor: 5.157

5. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase.

Authors: A Haghighat; Y Svitkin; I Novoa; E Kuechler; T Skern; N Sonenberg
Journal: J Virol Date: 1996-12 Impact factor: 5.103

6. Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation.

Authors: H D Liebig; E Ziegler; R Yan; K Hartmuth; H Klump; H Kowalski; D Blaas; W Sommergruber; L Frasel; B Lamphear
Journal: Biochemistry Date: 1993-07-27 Impact factor: 3.162

7. Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma.

Authors: R Yan; W Rychlik; D Etchison; R E Rhoads
Journal: J Biol Chem Date: 1992-11-15 Impact factor: 5.157

8. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation.

Authors: B J Lamphear; R Kirchweger; T Skern; R E Rhoads
Journal: J Biol Chem Date: 1995-09-15 Impact factor: 5.157

9. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.

Authors: S Mader; H Lee; A Pause; N Sonenberg
Journal: Mol Cell Biol Date: 1995-09 Impact factor: 4.272

10. Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin.

Authors: E Ziegler; A M Borman; R Kirchweger; T Skern; K M Kean
Journal: J Virol Date: 1995-06 Impact factor: 5.103

12 in total

1. Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes.

Authors: Kelly Watters; Ann C Palmenberg
Journal: J Virol Date: 2011-08-10 Impact factor: 5.103

2. Specific cleavage of the nuclear pore complex protein Nup62 by a viral protease.

Authors: Nogi Park; Tim Skern; Kurt E Gustin
Journal: J Biol Chem Date: 2010-07-09 Impact factor: 5.157

3. VIGOR, an annotation program for small viral genomes.

Authors: Shiliang Wang; Jaideep P Sundaram; David Spiro
Journal: BMC Bioinformatics Date: 2010-09-07 Impact factor: 3.169

4. Cardiovirus 2A protein associates with 40S but not 80S ribosome subunits during infection.

Authors: Rachel Groppo; Ann C Palmenberg
Journal: J Virol Date: 2007-08-29 Impact factor: 5.103

5. Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection.

Authors: Erin Walker; Lora Jensen; Sarah Croft; Kejun Wei; Alex J Fulcher; David A Jans; Reena Ghildyal
Journal: J Virol Date: 2016-11-28 Impact factor: 5.103

6. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.

Authors: Alessandra Gradi; Nicole Foeger; Rebecca Strong; Yuri V Svitkin; Nahum Sonenberg; Tim Skern; Graham J Belsham
Journal: J Virol Date: 2004-04 Impact factor: 5.103