Literature DB >> 12663803

Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism.

Sonia Navas1, Susan R Weiss.   

Abstract

Recombinant murine coronaviruses, differing only in the spike gene and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the background of the JHM genome, were compared for the ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice. Interestingly, expression of the A59 spike glycoprotein within the background of the neurotropic JHM strain does not reproduce the A59 hepatotropic phenotype. Thus, the JHM genetic background plays a dominant role over the spike in the determination of hepatotropism.

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Year:  2003        PMID： 12663803      PMCID： PMC152168          DOI： 10.1128/jvi.77.8.4972-4978.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  38 in total

1.  The severity of hepatic lesion after intraperitoneal JHMV infection in IFN-gamma deficient mice is parallel to viral replication in hepatocytes in vitro.

Authors:  S Kyuwa; S Kawamura; S Shibata; K Machii; Y Tagawa; Y Iwakura; T Urano
Journal:  Adv Exp Med Biol       Date:  2001       Impact factor: 2.622

2.  Murine coronavirus spike glycoprotein. Receptor binding and membrane fusion activities.

Authors:  T M Gallagher
Journal:  Adv Exp Med Biol       Date:  2001       Impact factor: 2.622

Review 3.  MHV infection of the CNS: mechanisms of immune-mediated control.

Authors:  N W Marten; S A Stohlman; C C Bergmann
Journal:  Viral Immunol       Date:  2001       Impact factor: 2.257

4.  Inactivation of expression of gene 4 of mouse hepatitis virus strain JHM does not affect virulence in the murine CNS.

Authors:  E Ontiveros; L Kuo; P S Masters; S Perlman
Journal:  Virology       Date:  2001-10-25       Impact factor: 3.616

5.  Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus.

Authors:  J Das Sarma; L Fu; J C Tsai; S R Weiss; E Lavi
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

6.  Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis.

Authors:  S Navas; S H Seo; M M Chua; J Das Sarma; E Lavi; S T Hingley; S R Weiss
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

Review 7.  Coronavirus spike proteins in viral entry and pathogenesis.

Authors:  T M Gallagher; M J Buchmeier
Journal:  Virology       Date:  2001-01-20       Impact factor: 3.616

Review 8.  Reverse genetics of the largest RNA viruses.

Authors:  P S Masters
Journal:  Adv Virus Res       Date:  1999       Impact factor: 9.937

Review 9.  Mouse hepatitis virus.

Authors:  J Haring; S Perlman
Journal:  Curr Opin Microbiol       Date:  2001-08       Impact factor: 7.934

10.  Kupffer and endothelial liver cell damage renders A/J mice susceptible to mouse hepatitis virus type 3.

Authors:  C A Pereira; A M Steffan; A Kirn
Journal:  Virus Res       Date:  1984-10       Impact factor: 3.303
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  38 in total

1.  Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome.

Authors:  Sonia Navas-Martin; Maarten Brom; Ming-Ming Chua; Richard Watson; Zhaozhu Qiu; Susan R Weiss
Journal:  J Virol       Date:  2006-11-01       Impact factor: 5.103

2.  Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence.

Authors:  Lubna Kazi; Arjen Lissenberg; Richard Watson; Raoul J de Groot; Susan R Weiss
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

3.  Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus.

Authors:  Ling Zhao; Kristine M Rose; Ruth Elliott; Nico Van Rooijen; Susan R Weiss
Journal:  J Virol       Date:  2011-07-13       Impact factor: 5.103

4.  Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence.

Authors:  Katherine C MacNamara; Ming Ming Chua; Joanna J Phillips; Susan R Weiss
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

5.  Both spike and background genes contribute to murine coronavirus neurovirulence.

Authors:  Kathryn T Iacono; Lubna Kazi; Susan R Weiss
Journal:  J Virol       Date:  2006-07       Impact factor: 5.103

6.  The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU.

Authors:  Rong Zhang; Yize Li; Timothy J Cowley; Adam D Steinbrenner; Judith M Phillips; Boyd L Yount; Ralph S Baric; Susan R Weiss
Journal:  J Virol       Date:  2015-01-14       Impact factor: 5.103

7.  Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.

Authors:  Jessica K Roth-Cross; Helen Stokes; Guohui Chang; Ming Ming Chua; Volker Thiel; Susan R Weiss; Alexander E Gorbalenya; Stuart G Siddell
Journal:  J Virol       Date:  2009-01-28       Impact factor: 5.103

8.  The murine coronavirus nucleocapsid gene is a determinant of virulence.

Authors:  Timothy J Cowley; Simon Y Long; Susan R Weiss
Journal:  J Virol       Date:  2009-12-09       Impact factor: 5.103

9.  Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia.

Authors:  Jessica K Roth-Cross; Susan J Bender; Susan R Weiss
Journal:  J Virol       Date:  2008-07-30       Impact factor: 5.103

10.  Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins.

Authors:  Erik Prentice; Josephine McAuliffe; Xiaotao Lu; Kanta Subbarao; Mark R Denison
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103
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