Literature DB >> 12663349

Claims for the anabolic effects of growth hormone: a case of the emperor's new clothes?

M J Rennie1.   

Abstract

This review examines the evidence that growth hormone has metabolic effects in adult human beings. The conclusion is that growth hormone does indeed have powerful effects on fat and carbohydrate metabolism, and in particular promotes the metabolic use of adipose tissue triacylglycerol. However, there is no proof that net protein retention is promoted in adults, except possibly of connective tissue. The overexaggeration of the effects of growth hormone in muscle building is effectively promoting its abuse and thereby encouraging athletes and elderly men to expose themselves to increased risk of disease for little benefit.

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Year:  2003        PMID： 12663349      PMCID： PMC1724606          DOI： 10.1136/bjsm.37.2.100

Source DB:  PubMed          Journal:  Br J Sports Med        ISSN： 0306-3674            Impact factor:   13.800


  78 in total

1.  Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance.

Authors:  A Colao; A Cuocolo; P Marzullo; E Nicolai; D Ferone; A M Della Morte; R Pivonello; M Salvatore; G Lombardi
Journal:  J Clin Endocrinol Metab       Date:  2001-04       Impact factor: 5.958

2.  GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake.

Authors:  K H Lange; F Isaksson; M H Rasmussen; A Juul; J Bülow; M Kjaer
Journal:  Clin Endocrinol (Oxf)       Date:  2001-07       Impact factor: 3.478

Review 3.  Metabolic effects of growth hormone in humans.

Authors:  N Møller; J O Jørgensen; J Møller; L Orskov; P Ovesen; O Schmitz; J S Christiansen; H Orskov
Journal:  Metabolism       Date:  1995-10       Impact factor: 8.694

4.  Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.

Authors:  J D Veldhuis; A Y Liem; S South; A Weltman; J Weltman; D A Clemmons; R Abbott; T Mulligan; M L Johnson; S Pincus
Journal:  J Clin Endocrinol Metab       Date:  1995-11       Impact factor: 5.958

5.  Effects of growth hormone overproduction on grip strength of transgenic mice.

Authors:  E Wolf; R Wanke; E Schenck; W Hermanns; G Brem
Journal:  Eur J Endocrinol       Date:  1995-12       Impact factor: 6.664

6.  Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men.

Authors:  D R Taaffe; I H Jin; T H Vu; A R Hoffman; R Marcus
Journal:  J Clin Endocrinol Metab       Date:  1996-01       Impact factor: 5.958

Review 7.  Adjunctive human growth hormone therapy in nutrition support: potential to limit septic complications in intensive care unit patients.

Authors:  T R Ziegler; I Leader
Journal:  Semin Respir Infect       Date:  1994-12

8.  Insulin and insulin-like growth factor-I enhance human skeletal muscle protein anabolism during hyperaminoacidemia by different mechanisms.

Authors:  D A Fryburg; L A Jahn; S A Hill; D M Oliveras; E J Barrett
Journal:  J Clin Invest       Date:  1995-10       Impact factor: 14.808

9.  Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle.

Authors:  G Biolo; R Y Declan Fleming; R R Wolfe
Journal:  J Clin Invest       Date:  1995-02       Impact factor: 14.808

10.  Effect of growth hormone and resistance exercise on muscle growth and strength in older men.

Authors:  K E Yarasheski; J J Zachwieja; J A Campbell; D M Bier
Journal:  Am J Physiol       Date:  1995-02
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  30 in total

Review 1.  Effects of growth hormone and prolactin on adipose tissue development and function.

Authors:  David J Flint; Nadine Binart; John Kopchick; Paul Kelly
Journal:  Pituitary       Date:  2003-09       Impact factor: 4.107

2.  Growth hormone: uses and abuses.

Authors:  Raymond L Hintz
Journal:  BMJ       Date:  2004-04-17

3.  Growth hormone responses to acute resistance exercise with vascular restriction in young and old men.

Authors:  Todd M Manini; Joshua F Yarrow; Thomas W Buford; Brian C Clark; Christine F Conover; Stephen E Borst
Journal:  Growth Horm IGF Res       Date:  2012-06-23       Impact factor: 2.372

Review 4.  How nutrition and exercise maintain the human musculoskeletal mass.

Authors:  Henning Wackerhage; Michael J Rennie
Journal:  J Anat       Date:  2006-04       Impact factor: 2.610

5.  Hypertrophy with unilateral resistance exercise occurs without increases in endogenous anabolic hormone concentration.

Authors:  Sarah B Wilkinson; Mark A Tarnopolsky; Emily J Grant; Caroline E Correia; Stuart M Phillips
Journal:  Eur J Appl Physiol       Date:  2006-09-14       Impact factor: 3.078

Review 6.  Performance-enhancing substances in sports: a review of the literature.

Authors:  Amit Momaya; Marc Fawal; Reed Estes
Journal:  Sports Med       Date:  2015-04       Impact factor: 11.136

7.  Growth hormone 1 (GH1) gene and performance and post-race rectal temperature during the South African Ironman triathlon.

Authors:  B Walpole; T D Noakes; M Collins
Journal:  Br J Sports Med       Date:  2006-02       Impact factor: 13.800

8.  Human growth hormone: 45-kDa isoform with extraordinarily stable interchain disulfide links has attenuated receptor-binding and cell-proliferative activities.

Authors:  Juan J Bustamante; Alexei L Grigorian; Jesus Muñoz; Roberto M Aguilar; Lisa R Treviño; Andrew O Martinez; Luis S Haro
Journal:  Growth Horm IGF Res       Date:  2010-05-15       Impact factor: 2.372

9.  Physiological elevation of endogenous hormones results in superior strength training adaptation.

Authors:  Bent R Rønnestad; Håvard Nygaard; Truls Raastad
Journal:  Eur J Appl Physiol       Date:  2011-02-16       Impact factor: 3.078

10.  Effects of genistein on stereological and hormonal characteristics of the pituitary somatotrophs in rats.

Authors:  Svetlana Trifunović; Milica Manojlović-Stojanoski; Vladimir Ajdžanović; Nataša Nestorović; Nataša Ristić; Ivana Medigović; Verica Milošević
Journal:  Endocrine       Date:  2014-04-22       Impact factor: 3.633
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