Literature DB >> 12663142

Interferon gamma and lipopolysaccharide upregulate TNF-related apoptosis-inducing ligand expression in murine microglia.

Sermin Genc1, Sefa Kizildag, Kursad Genc, Halil Ates, Nese Atabey, Sefa Kizyldag.   

Abstract

In this study, it is reported that neonatal murine microglia and N9 murine microglial cell line express tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL). TRAIL protein and mRNA expression in murine microglia greatly upregulate upon stimulation with interferon gamma (IFNgamma) or lipopolysaccharide (LPS) as revealed by immunoprecipitation-immunoblotting, reverse transcriptase-polymerase chain reaction (RT-PCR) and flow cytometry techniques. IFNgamma and LPS act synergistically to induce TRAIL expression on both translational and transcriptional levels. The upregulated microglial TRAIL in inflammatory conditions may involve in the cytotoxic effect of these cells and play a role in neurodegenerative processes.

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Year:  2003        PMID： 12663142     DOI： 10.1016/s0165-2478(02)00245-6

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  8 in total

Review 1.  The signaling and apoptotic effects of TNF-related apoptosis-inducing ligand in HIV-1 associated dementia.

Authors:  Y Huang; N Erdmann; J Zhao; J Zheng
Journal:  Neurotox Res       Date:  2005-10       Impact factor: 3.911

2.  TNF-related apoptosis-inducing ligand level in Alzheimer's disease.

Authors:  Sermin Genc; Mehtap Yuksel Egrilmez; Erdem Yaka; Zahide Cavdar; Leyla Iyilikci; Gorsev Yener; Kursad Genc
Journal:  Neurol Sci       Date:  2009-03-18       Impact factor: 3.307

Review 3.  Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in central nervous system inflammation.

Authors:  Olaf Hoffmann; Frauke Zipp; Joerg R Weber
Journal:  J Mol Med (Berl)       Date:  2009-05-17       Impact factor: 4.599

4.  MicroRNAs and Multiple Sclerosis.

Authors:  Kemal Ugur Tufekci; Meryem Gulfem Oner; Sermin Genc; Kursad Genc
Journal:  Autoimmune Dis       Date:  2010-11-11

5.  The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model.

Authors:  Tsung-Lang Chiu; Mei-Jan Wang; Chin-Cheng Su
Journal:  J Biomed Sci       Date:  2012-04-22       Impact factor: 8.410

6.  MiR-98 Protects Nucleus Pulposus Cells against Apoptosis by Targeting TRAIL in Cervical Intervertebral Disc Degeneration.

Authors:  Shimin Xu; Yuezhong Li; Junshan Zhang; Zhiwei Li; Yanping Xing
Journal:  J Healthc Eng       Date:  2022-01-25       Impact factor: 2.682

7.  Follow-up Analysis of Serum TNF-Related Apoptosis-Inducing Ligand Protein and mRNA Expression in Peripheral Blood Mononuclear Cells from Patients with Ischemic Stroke.

Authors:  Kemal Ugur Tufekci; Ufuk Vurgun; Onur Yigitaslan; Pembe Keskinoglu; Erdem Yaka; Kursad Kutluk; Sermin Genc
Journal:  Front Neurol       Date:  2018-03-05       Impact factor: 4.003

Review 8.  Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson's Disease: A Review.

Authors:  Dicson Sheeja Malar; Mani Iyer Prasanth; James Michael Brimson; Rajasekharan Sharika; Bhagavathi Sundaram Sivamaruthi; Chaiyavat Chaiyasut; Tewin Tencomnao
Journal:  Molecules       Date:  2020-08-27       Impact factor: 4.411
  8 in total

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