BACKGROUND: A correlation between elevation of pro-inflammatory cytokines and white matter injury or abnormal neurologic outcome has been established in the preterm infant. In the full-term neonate, few studies exist linking elevation of cytokines with encephalopathy and poor neurodevelopmental outcome. Our aims were to investigate if serum interleukin-6 concentrations in delivering mothers and their offspring at birth are associated with perinatal asphyxia, and to examine the relation of interleukin-6 levels to the severity of hypoxic-ischemic encephalopathy and to the neurological outcome. DESIGN AND METHODS: Serum interleukin-6 levels were measured at birth, 24 and 48 h of life in 50 consecutive term uninfected newborns with perinatal asphyxia and 113 randomly selected healthy term newborns, and at delivery in their mothers. RESULTS: The median cord interleukin-6 concentrations in the infants who developed hypoxic-ischemic encephalopathy was 376-fold as high as the values in the normal infants (P < 0.0001) and 5.5-fold as high as those in the infants with asphyxia who did not develop hypoxic-ischemic encephalopathy (P < 0.05). There was also a significant relationship between interleukin-6 and the degree of hypoxic-ischemic encephalopathy, and between interleukin-6 and neurodevelopmental outcome at 2 years of age. Regardless of outcome, in the asphyxiated infants the interleukin-6 values were significantly lower at both 24 and 48 h of life than at birth, with a significant decline from 24 to 48 h of life. Among mothers of the asphyxiated neonates, there were no significant differences in interleukin-6 concentrations between those delivering neonates with and without hypoxic-ischemic encephalopathy. CONCLUSIONS: Measurement of IL-6 concentrations in the umbilical cord of neonates with perinatal asphyxia may be useful to identify early, and in a relatively simple way, those who are most likely to have subsequent brain injury and adverse outcome.
BACKGROUND: A correlation between elevation of pro-inflammatory cytokines and white matter injury or abnormal neurologic outcome has been established in the preterm infant. In the full-term neonate, few studies exist linking elevation of cytokines with encephalopathy and poor neurodevelopmental outcome. Our aims were to investigate if serum interleukin-6 concentrations in delivering mothers and their offspring at birth are associated with perinatal asphyxia, and to examine the relation of interleukin-6 levels to the severity of hypoxic-ischemicencephalopathy and to the neurological outcome. DESIGN AND METHODS: Serum interleukin-6 levels were measured at birth, 24 and 48 h of life in 50 consecutive term uninfected newborns with perinatal asphyxia and 113 randomly selected healthy term newborns, and at delivery in their mothers. RESULTS: The median cord interleukin-6 concentrations in the infants who developed hypoxic-ischemicencephalopathy was 376-fold as high as the values in the normal infants (P < 0.0001) and 5.5-fold as high as those in the infants with asphyxia who did not develop hypoxic-ischemicencephalopathy (P < 0.05). There was also a significant relationship between interleukin-6 and the degree of hypoxic-ischemicencephalopathy, and between interleukin-6 and neurodevelopmental outcome at 2 years of age. Regardless of outcome, in the asphyxiated infants the interleukin-6 values were significantly lower at both 24 and 48 h of life than at birth, with a significant decline from 24 to 48 h of life. Among mothers of the asphyxiated neonates, there were no significant differences in interleukin-6 concentrations between those delivering neonates with and without hypoxic-ischemicencephalopathy. CONCLUSIONS: Measurement of IL-6 concentrations in the umbilical cord of neonates with perinatal asphyxia may be useful to identify early, and in a relatively simple way, those who are most likely to have subsequent brain injury and adverse outcome.
Authors: Jiyong Zhang; Grazyna B Sadowska; Xiaodi Chen; Seon Yeong Park; Jeong-Eun Kim; Courtney A Bodge; Erin Cummings; Yow-Pin Lim; Oleksandr Makeyev; Walter G Besio; John Gaitanis; William A Banks; Barbara S Stonestreet Journal: FASEB J Date: 2015-01-21 Impact factor: 5.191
Authors: Michael W Varner; Nicole E Marshall; Dwight J Rouse; Kathleen A Jablonski; Kenneth J Leveno; Uma M Reddy; Brian M Mercer; Jay D Iams; Ronald J Wapner; Yoram Sorokin; John M Thorp; Fergal D Malone; Marshall Carpenter; Mary J O'Sullivan; Alan M Peaceman; Gary D V Hankins; Donald J Dudley; Steve N Caritis Journal: Am J Perinatol Date: 2014-06-17 Impact factor: 1.862
Authors: Victor Camera Pimentel; Jéssica Lopes Gomes; Daniela Zanini; Fátima Husein Abdalla; Pauline da Costa; Jamile Fabbrin Gonçalves; Marta Maria Medeiros Frescura Duarte; Maria Beatriz Moretto; Vera Maria Morsch; Maria Rosa Chitolina Schetinger Journal: Mol Cell Biochem Date: 2013-03-21 Impact factor: 3.396
Authors: Ingran Lingam; Adnan Avdic-Belltheus; Christopher Meehan; Kathryn Martinello; Sara Ragab; Donald Peebles; Melinda Barkhuizen; Cally J Tann; Ilias Tachtsidis; Tim G A M Wolfs; Henrik Hagberg; Nigel Klein; Bobbi Fleiss; Pierre Gressens; Xavier Golay; Boris W Kramer; Nicola J Robertson Journal: Pediatr Res Date: 2020-06-10 Impact factor: 3.756