Literature DB >> 12662130

The role of GABA in anxiety disorders.

R Bruce Lydiard1.   

Abstract

Anxiety stems from and perpetuates dysregulation of neurobiological systems, but the exact mechanisms of anxiety disorders are still only partially understood. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known to counterbalance the action of the excitatory neurotransmitter glutamate. Several pharmacologic agents target the GABA system and modulate the overall effect of GABA. This article highlights multiple neurobiological interactions that play a role in anxiety and reviews selected studies of plasma neurosteroid levels, plasma GABA levels, and benzodiazepine binding site sensitivity and density in patients with anxiety disorders. The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders.

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Year:  2003        PMID： 12662130

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  82 in total

1.  GABAA Receptor Density Is Not Altered by a Novel Herbal Anxiolytic Treatment.

Authors:  Ravid Doron; Avital Sever; Assaf Handelsman; Roni Toledano; Motty Franko; Yafit Hirshler; Alon Shamir; Or Burstein; Moshe Rehavi
Journal:  J Mol Neurosci       Date:  2018-05-08       Impact factor: 3.444

Review 2.  [Patients with epilepsy and anxiety disorders. Diagnosis and treatment].

Authors:  S Beyenburg; D Schmidt
Journal:  Nervenarzt       Date:  2005-09       Impact factor: 1.214

Review 3.  GABAA receptor trafficking-mediated plasticity of inhibitory synapses.

Authors:  Bernhard Luscher; Thomas Fuchs; Casey L Kilpatrick
Journal:  Neuron       Date:  2011-05-12       Impact factor: 17.173

4.  Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice.

Authors:  Timothy A Warner; Zhong Liu; Robert L Macdonald; Jing-Qiong Kang
Journal:  Epilepsy Res       Date:  2017-04-30       Impact factor: 3.045

5.  New knockout model confirms a role for androgen receptors in regulating anxiety-like behaviors and HPA response in mice.

Authors:  Chieh V Chen; Jennifer L Brummet; Joseph S Lonstein; Cynthia L Jordan; S Marc Breedlove
Journal:  Horm Behav       Date:  2014-01-15       Impact factor: 3.587

6.  GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice.

Authors:  Jonas Waider; Florian Proft; Georg Langlhofer; Esther Asan; Klaus-Peter Lesch; Lise Gutknecht
Journal:  Histochem Cell Biol       Date:  2012-10-11       Impact factor: 4.304

7.  Ultrahigh field MR Neuroimaging.

Authors:  Gaurav Verma; Priti Balchandani
Journal:  Top Magn Reson Imaging       Date:  2019-06

8.  Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.

Authors:  Yuan Ge; Yunhee Kang; Robert M Cassidy; Kyung-Mee Moon; Renate Lewis; Rachel O L Wong; Leonard J Foster; Ann Marie Craig
Journal:  Neuron       Date:  2018-01-25       Impact factor: 17.173

Review 9.  MicroRNA's impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety.

Authors:  Stefanie Martinetz
Journal:  Pflugers Arch       Date:  2016-04-30       Impact factor: 3.657

Review 10.  Antiepileptic drugs in the treatment of anxiety disorders: role in therapy.

Authors:  Michael Van Ameringen; Catherine Mancini; Beth Pipe; Mark Bennett
Journal:  Drugs       Date:  2004       Impact factor: 9.546
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