Literature DB >> 12662110

Three new cytotoxic sesterterpenes from a marine sponge Spongia sp.

Sachiko Tsukamoto1, Shunsuke Miura, Rob W M van Soest, Tomihisa Ohta.   

Abstract

Three new sesterterpenes (1-3) were isolated from a marine sponge of the genus Spongia, and their structures were determined on the basis of spectroscopic analysis. The compounds 1-3 exhibited cytotoxicity against HeLa cells with IC(50) values of 19.5, 15.0, and 5.3 microg/mL, respectively.

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Year:  2003        PMID： 12662110     DOI： 10.1021/np020497l

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

Review 1.  The Role of Spongia sp. in the Discovery of Marine Lead Compounds.

Authors:  Patrícia Máximo; Luísa M Ferreira; Paula Branco; Pedro Lima; Ana Lourenço
Journal:  Mar Drugs       Date:  2016-07-23       Impact factor: 5.118

2.  Chemistry of Glossodoris nudibranchs: specific occurrence of 12-keto scalaranes.

Authors:  Emiliano Manzo; Margherita Gavagnin; Michael J Somerville; Shui-Chun Mao; M Letizia Ciavatta; Ernesto Mollo; Peter J Schupp; Mary J Garson; Yue-Wei Guo; Guido Cimino
Journal:  J Chem Ecol       Date:  2007-11-15       Impact factor: 2.626

3.  The marine natural product Scalarin inhibits the receptor for advanced glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic cancer cell lines.

Authors:  Esther Amalia Guzmán; Tara Peterson Pitts; Maria Cristina Diaz; Amy Elizabeth Wright
Journal:  Invest New Drugs       Date:  2018-07-12       Impact factor: 3.850

4.  Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.

Authors:  Inho Yang; Jusung Lee; Jihye Lee; Dongyup Hahn; Jungwook Chin; Dong Hwan Won; Jaeyoung Ko; Hyukjae Choi; Ahreum Hong; Sang-Jip Nam; Heonjoong Kang
Journal:  Molecules       Date:  2018-12-03       Impact factor: 4.411

5.  An Anti-Inflammatory 2,4-Cyclized-3,4-Secospongian Diterpenoid and Furanoterpene-Related Metabolites of a Marine Sponge Spongia sp. from the Red Sea.

Authors:  Chi-Jen Tai; Chiung-Yao Huang; Atallah F Ahmed; Raha S Orfali; Walied M Alarif; Yusheng M Huang; Yi-Hsuan Wang; Tsong-Long Hwang; Jyh-Horng Sheu
Journal:  Mar Drugs       Date:  2021-01-16       Impact factor: 5.118

6.  Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus.

Authors:  Abdulrahman M Alahdal; Hani Z Asfour; Safwat A Ahmed; Ahmad O Noor; Ahmed M Al-Abd; Mahmoud A Elfaky; Sameh S Elhady
Journal:  Molecules       Date:  2018-04-23       Impact factor: 4.411

7.  Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus.

Authors:  Oh-Seok Kwon; Donghwa Kim; Chang-Kwon Kim; Jeongyoon Sun; Chung J Sim; Dong-Chan Oh; Sang Koo Lee; Ki-Bong Oh; Jongheon Shin
Journal:  Mar Drugs       Date:  2020-05-13       Impact factor: 5.118
  7 in total

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