Literature DB >> 12660929

Immunogenicity and immunological priming of the serogroup a portion of a bivalent meningococcal A/C conjugate vaccine in 2-year-old children.

Helen Joseph1, Robert Ryall, Mike Bybel, Thomas Papa, Jenny MacLennan, Jim Buttery, Raymond Borrow.   

Abstract

Two-year-old children were vaccinated with 1 dose of meningococcal A/C conjugate (MACC) or meningococcal A/C polysaccharide (MACP) vaccine. Meningococcal serogroup A (MenA)-specific IgG geometric mean avidity indices (GMAIs) increased 1 month after vaccination with MACC (GMAI, 210; 95% confidence interval [CI], 140-300) and MACP (GMAI, 190; 95% CI, 120-310). One year after vaccination, the GMAI of the MACP-vaccinated cohort decreased to 130 (95%, CI 100-170), but a constant GMAI was maintained in the MACC-vaccinated cohort (210; 95% CI, 140-300), despite declining MenA-specific IgG antibody levels.

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Year:  2003        PMID： 12660929     DOI： 10.1086/368358

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  6 in total

1.  Conjugates of group A and W135 capsular polysaccharides of neisseria meningitidis bound to recombinant Staphylococcus aureus enterotoxin C1: preparation, physicochemical characterization, and immunological properties in mice.

Authors:  Zhigang Jin; Gregory A Bohach; Joseph Shiloach; Scott E Norris; Darón I Freedberg; Claudia Deobald; Bruce Coxon; John B Robbins; Rachel Schneerson
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

Review 2.  Protein carriers of conjugate vaccines: characteristics, development, and clinical trials.

Authors:  Michael E Pichichero
Journal:  Hum Vaccin Immunother       Date:  2013-08-16       Impact factor: 3.452

3.  Serum antibody responses in Ethiopian meningitis patients infected with Neisseria meningitidis serogroup A sequence type 7.

Authors:  Gunnstein Norheim; Abraham Aseffa; Mohammed Ahmed Yassin; Getahun Mengistu; Afework Kassu; Dereje Fikremariam; Wegene Tamire; Yared Merid; E Arne Høiby; Dominique A Caugant; Elisabeth Fritzsønn; Torill Tangen; Tsegaye Alebel; Degu Berhanu; Morten Harboe; Einar Rosenqvist
Journal:  Clin Vaccine Immunol       Date:  2007-02-14

4.  Immunologic hyporesponsiveness to serogroup C but not serogroup A following repeated meningococcal A/C polysaccharide vaccination in Saudi Arabia.

Authors:  Hani Jokhdar; Ray Borrow; Abdulrazaq Sultan; Mousaed Adi; Christine Riley; Emily Fuller; David Baxter
Journal:  Clin Diagn Lab Immunol       Date:  2004-01

5.  Investigation of different group A immunoassays following one dose of meningococcal group A conjugate vaccine or A/C polysaccharide vaccine in adults.

Authors:  H Findlow; B D Plikaytis; A Aase; M C Bash; H Chadha; C Elie; G Laher; J Martinez; T Herstad; E Newton; S Viviani; C Papaspyridis; P Kulkarni; M Wilding; M P Preziosi; E Marchetti; M Hassan-King; F M La Force; G Carlone; R Borrow
Journal:  Clin Vaccine Immunol       Date:  2009-05-27

6.  Combined meningococcal serogroup A and W135 outer-membrane vesicles activate cell-mediated immunity and long-term memory responses against non-covalent capsular polysaccharide A.

Authors:  Belkis Romeu; Miriam Lastre; Luis García; Bárbara Cedré; Aleida Mandariote; Mildrey Fariñas; Reynaldo Oliva; Einar Rosenqvist; Oliver Pérez
Journal:  Immunol Res       Date:  2014-01       Impact factor: 2.829
  6 in total

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