| Literature DB >> 12659774 |
Apos Dermatakis1, Kin Chun Luk, Wanda DePinto.
Abstract
A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitution afforded agents with increased potency relative to the parent indolinone and nanomolar range IC(50) against the CDK2 enzyme and two cancer cell lines.Entities:
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Year: 2003 PMID： 12659774 DOI： 10.1016/s0968-0896(03)00036-1
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641