Literature DB >> 12659749

Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors.

Wendelin Frick1, Andrea Bauer-Schäfer, Jochen Bauer, Frank Girbig, Daniel Corsiero, Hubert Heuer, Werner Kramer.   

Abstract

The design and synthesis of a biotin-tagged photoreactive analogue C-4 of the cholesterol absorption inhibitor Ezetimibe is described. Photoaffinity labeling of intestinal brush border membrane vesicles with C-4 and subsequent streptavidin-biotin chromatography leads to selective extraction of a 145 kDa integral membrane protein as the molecular target for cholesterol absorption inhibitors.

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Year:  2003        PMID： 12659749     DOI： 10.1016/s0968-0896(03)00047-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ.

Authors:  Ki Duk Park; Dongwook Kim; Onrapak Reamtong; Claire Eyers; Simon J Gaskell; Rihe Liu; Harold Kohn
Journal:  J Am Chem Soc       Date:  2011-07-06       Impact factor: 15.419

Review 2.  Antilipidemic Drug Therapy Today and in the Future.

Authors:  Werner Kramer
Journal:  Handb Exp Pharmacol       Date:  2016

Review 3.  Hypolipidemic therapy and cholesterol absorption.

Authors:  Amit Manhas; John A Farmer
Journal:  Curr Atheroscler Rep       Date:  2004-03       Impact factor: 5.113

4.  Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors.

Authors:  Yubin Wang; Wenlong Huang; Huibin Zhang; Jinpei Zhou
Journal:  Lett Drug Des Discov       Date:  2011-07       Impact factor: 1.150
  4 in total

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