| Literature DB >> 12659579 |
Masaaki Sakurai1, Maki Nishio, Kouzou Yamamoto, Toru Okuda, Kimio Kawano, Tetsuo Ohnuki.
Abstract
[structure: see text] TMC-264 (1), a novel tricyclic heptaketide with a unique chloro-1H-dibenzo[b,d]pyran-4,6-dione skeleton, was discovered from the fungus Phoma sp. TC 1674. The structure was elucidated on the basis of NMR analyses of normal abundance and biosynthetically (13)C-enriched TMC-264. TMC-264 showed potent inhibitory activity against tyrosine phosphorylation of STAT6.Entities:
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Year: 2003 PMID： 12659579 DOI： 10.1021/ol034125v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005