Literature DB >> 12658761

An experimental study on the expression of heme oxygenase-2 mRNA in Hirschsprung's disease.

Min Zhu1, Mingfa Wei, Fang Liu.   

Abstract

In order to investigate the relationship between the expression of heme oxygenase-2 (HO-2) mRNA and the pathogenesis of Hirschsprung's disease (HD), total ribonucleic acid (RNA) was extracted in the aganglionic and ganglionic segments of colon respectively from 15 cases of HD. The single-stranded cDNA of HO-2 was synthesized and further amplified by reverse transcription-polymerase chain reaction (RT-PCR). The expression of HO-2 mRNA was normal in ganglionic segments, but absent in aganglionic segments. It is concluded that the absence of HO-2 mRNA expression may be an important mechanism responsible for HD.

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Year:  2002        PMID： 12658761     DOI： 10.1007/BF02857681

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  6 in total

1.  Morphological relations between haem oxygenases, NO-synthase and VIP in the canine and feline gastrointestinal tracts.

Authors:  L Ny; P Alm; B Larsson; K E Andersson
Journal:  J Auton Nerv Syst       Date:  1997-07-14

Review 2.  The heme oxygenase system: a regulator of second messenger gases.

Authors:  M D Maines
Journal:  Annu Rev Pharmacol Toxicol       Date:  1997       Impact factor: 13.820

3.  Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase.

Authors:  R Battish; G Y Cao; R B Lynn; S Chakder; S Rattan
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-01       Impact factor: 4.052

4.  Contribution of carbon monoxide-producing cells in the gastric mucosa of rat and monkey.

Authors:  Y Hu; M Yang; N Ma; H Shinohara; R Semba
Journal:  Histochem Cell Biol       Date:  1998-04       Impact factor: 4.304

5.  Distribution of heme oxygenase 2 in nerves and c-kit(+) interstitial cells in human stomach.

Authors:  C Porcher; P Orsoni; S Berdah; G Monges; B Mazet
Journal:  Histochem Cell Biol       Date:  1999-10       Impact factor: 4.304

6.  Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: evidence from genomic deletion of biosynthetic enzymes.

Authors:  L Xue; G Farrugia; S M Miller; C D Ferris; S H Snyder; J H Szurszewski
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205
  6 in total

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