Giuseppe Citerio1, Manuela Cormio. 1. Dipartimento di Anestesia e Rianimazone, Nuovo Ospedale San Gerardo, Monza, Italy. g.citerio@hsgerardo.org
Abstract
PURPOSE OF REVIEW: To evaluate the rationale and the pharmacologic options for sedating neurointensive care patients. RECENT FINDINGS: Sedation is a fundamental element in the neurointensive care unit. Even if the sedative strategy in the neurointensive care unit shares the same general aims with intensive care, the characteristics of the patients in the neurointensive care unit pose other unique challenges and some specific indications. The primary aim of neurointensive care is to maintain adequate cerebral perfusion pressure, to control intracranial pressure, and to maintain an adequate mean arterial pressure. Reducing the brain's metabolic demand is an important treatment strategy, and analgesic and sedative agents are used to prevent undesirable increases in intracranial pressure. There are many different pharmacologic agents available, each with distinct advantages and disadvantages. SUMMARY: The pharmacokinetic and pharmacologic effects of the available sedatives used in neurointensive care patients are reviewed. Copyright 2003 Lippincott Williams & Wilkins
PURPOSE OF REVIEW: To evaluate the rationale and the pharmacologic options for sedating neurointensive care patients. RECENT FINDINGS: Sedation is a fundamental element in the neurointensive care unit. Even if the sedative strategy in the neurointensive care unit shares the same general aims with intensive care, the characteristics of the patients in the neurointensive care unit pose other unique challenges and some specific indications. The primary aim of neurointensive care is to maintain adequate cerebral perfusion pressure, to control intracranial pressure, and to maintain an adequate mean arterial pressure. Reducing the brain's metabolic demand is an important treatment strategy, and analgesic and sedative agents are used to prevent undesirable increases in intracranial pressure. There are many different pharmacologic agents available, each with distinct advantages and disadvantages. SUMMARY: The pharmacokinetic and pharmacologic effects of the available sedatives used in neurointensive care patients are reviewed. Copyright 2003 Lippincott Williams & Wilkins
Authors: Tarek Sharshar; Giuseppe Citerio; Peter J D Andrews; Arturo Chieregato; Nicola Latronico; David K Menon; Louis Puybasset; Claudio Sandroni; Robert D Stevens Journal: Intensive Care Med Date: 2014-02-13 Impact factor: 17.440
Authors: Jörg Martin; Anja Heymann; Katrin Bäsell; Ralf Baron; Rolf Biniek; Hartmut Bürkle; Peter Dall; Christine Dictus; Verena Eggers; Ingolf Eichler; Lothar Engelmann; Lars Garten; Wolfgang Hartl; Ulrike Haase; Ralf Huth; Paul Kessler; Stefan Kleinschmidt; Wolfgang Koppert; Franz-Josef Kretz; Heinz Laubenthal; Guenter Marggraf; Andreas Meiser; Edmund Neugebauer; Ulrike Neuhaus; Christian Putensen; Michael Quintel; Alexander Reske; Bernard Roth; Jens Scholz; Stefan Schröder; Dierk Schreiter; Jürgen Schüttler; Gerhard Schwarzmann; Robert Stingele; Peter Tonner; Philip Tränkle; Rolf Detlef Treede; Tomislav Trupkovic; Michael Tryba; Frank Wappler; Christian Waydhas; Claudia Spies Journal: Ger Med Sci Date: 2010-02-02