Literature DB >> 1265797

Synthesis of steroidal cyclophosphamides.

E L Foster, R T Blickenstaff.   

Abstract

The Reformatsky product of estrone methyl ether and ethyl bromo-acetate was transformed by two separate routes to 21-amino-3-methoxy-17alpha-pregna-1,3,5(10)-trien-17beta-ol (9). Cyclization with bis- (2-chloroethyl) phosphoramide dichloride produced the steroidal cyclophosphamide 10. Analogous syntheses transformed androstenolone into steroidal cyclophosphamide 20 and androstenedione into steroidal cyclophosphamide 28.

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Year:  1976        PMID： 1265797     DOI： 10.1016/0039-128x(76)90056-8

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  3 in total

1.  Synthesis, characterization and biological evaluation of some novel P-heterocyclic androst-4-ene derivatives.

Authors:  Natalija M Krstić; Vladimir D Pavlović; Irena T Novaković; Ivana Z Matić; Dušan M Sladić
Journal:  Mol Divers       Date:  2013-06-09       Impact factor: 2.943

2.  Cytostatic activity of steroid linked nitrosoureas.

Authors:  W J Zeller; J Schreiber; A D Ho; D Schmähl; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

3.  Evaluation of new estrogen-linked 2-chloroethylnitrosoureas. I. Short term anticancer efficacy in methylnitrosourea-induced rat mammary carcinoma and hormonal activity in mice.

Authors:  M R Berger; J Floride; J Schreiber; D Schmähl; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553
  3 in total

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