| Literature DB >> 12657283 |
Stephen L Gwaltney1, Stephen J O'Connor, Lissa T J Nelson, Gerard M Sullivan, Hovis Imade, Weibo Wang, Lisa Hasvold, Qun Li, Jerome Cohen, Wen-Zhen Gu, Stephen K Tahir, Joy Bauch, Kennan Marsh, Shi-Chung Ng, David J Frost, Haiying Zhang, Steve Muchmore, Clarissa G Jakob, Vincent Stoll, Charles Hutchins, Saul H Rosenberg, Hing L Sham.
Abstract
Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered bioavailable aryl tetrahydropyridines that are potent in cell culture. The design, synthesis, SAR and biological properties of these compounds will be discussed.Entities:
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Year: 2003 PMID： 12657283 DOI： 10.1016/s0960-894x(03)00094-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823