| Literature DB >> 12657259 |
María L Souto1, Claudia P Manríquez, Manuel Norte, Francisco Leira, José J Fernández.
Abstract
This paper reports testing 15 polyether triterpenes with a squalene carbon skeleton for inhibitory effects on type 2A protein phosphatase. Two compounds, 16-hydroxydehydrothyrsiferol 10 and thyrsenol B 14, exhibited significant inhibitory action at a concentration of 10 microM. Comparison with thyrsiferyl-23-acetate 1 showed that a similar spatial disposition for the hydroxy group around C-15 or C-16 was the structural feature shared by these metabolites.Entities:
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Year: 2003 PMID： 12657259 DOI： 10.1016/s0960-894x(03)00136-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823