| Literature DB >> 12657258 |
Armin Reichenberg1, Martin Hintz, Yvonne Kletschek, Tanja Kuhl, Christian Haug, Rosel Engel, Jens Moll, Dmitry N Ostrovsky, Hassan Jomaa, Matthias Eberl.
Abstract
The immunological characterization of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), and its methylenediphosphonate analogue, HMB-PCP, is described. With an EC(50) of 0.1-0.2 nM, HMB-PP is significantly more potent in stimulating human Vgamma9/Vdelta2 T cells than any other compound described so far. However, replacing the pyrophosphate by a P-CH(2)-P function abrogates the bioactivity drastically, with HMB-PCP having a EC(50) of only 5.3 microM.Entities:
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Year: 2003 PMID： 12657258 DOI： 10.1016/s0960-894x(03)00138-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823