| Literature DB >> 12657253 |
Percy H Carter1, Jacob R LaPorte, Peggy A Scherle, Carl P Decicco.
Abstract
A short, enantioselective, and diastereoselective synthesis of cytoxazone, a Th2-selective immunomodulator from Streptomyces, is described. The route was readily adapted to the synthesis of the three other stereoisomers of natural cytoxazone. Evaluation of these compounds revealed that the stereochemical configuration of the oxazolidinone ring did not influence their biological activity.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12657253 DOI： 10.1016/s0960-894x(03)00131-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823