| Literature DB >> 12657252 |
Guoxin Zhu1, Scott Conner, Xun Zhou, Chuan Shih, Harold B Brooks, Eileen Considine, Jack A Dempsey, Cathy Ogg, Bharvin Patel, Richard M Schultz, Charles D Spencer, Beverly Teicher, Scott A Watkins.
Abstract
A novel series of pyrrolo[3,4-c] carbazoles fused with a quinolinyl/isoquinolinyl moiety were synthesized and their D1/CDK4 inhibitory and antiproliferative activity were evaluated. Compound 8H, 14H-isoquinolinyl[6,5-a]-pyrrolo[3,4-c]carbazole-7,9-dione (1d) was found to be a highly potent D1/CDK4 inhibitor with an IC(50) of 69 nM. Compound 1d also inhibited tumor cell growth, arrested tumor cells in G1 phase and inhibited pRb phosphorylation.Entities:
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Year: 2003 PMID： 12657252 DOI： 10.1016/s0960-894x(03)00133-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823