Paddy McMaster1, Frank Shann. 1. Pediatric Intensive Care Unit, The Royal Children's Hospital, Melbourne, Australia.
Abstract
OBJECTIVE: To determine whether there is sufficient evidence of a benefit of hemofiltration or plasma filtration in sepsis. DATA SOURCES: Medline search, search of references in articles found in Medline search, literature known to local experts. STUDY SELECTION: Trials and reports where clinical outcome measures were included. DATA EXTRACTION: Clinically relevant information was presented. DATA SYNTHESIS: Studies were grouped according to hemofiltration or plasma filtration and within each of these groups into animal or human studies; then they were graded from case report, through case series, nonrandomized trials, and randomized trials. CONCLUSION: There is a lack of randomized trials. The available studies show an absence of benefit for hemofiltration. Further studies are needed in plasma filtration.
OBJECTIVE: To determine whether there is sufficient evidence of a benefit of hemofiltration or plasma filtration in sepsis. DATA SOURCES: Medline search, search of references in articles found in Medline search, literature known to local experts. STUDY SELECTION: Trials and reports where clinical outcome measures were included. DATA EXTRACTION: Clinically relevant information was presented. DATA SYNTHESIS: Studies were grouped according to hemofiltration or plasma filtration and within each of these groups into animal or human studies; then they were graded from case report, through case series, nonrandomized trials, and randomized trials. CONCLUSION: There is a lack of randomized trials. The available studies show an absence of benefit for hemofiltration. Further studies are needed in plasma filtration.