Literature DB >> 12655309

A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonist.

David Feifel1, Gilia Melendez, Paul D Shilling.   

Abstract

Prepulse inhibition (PPI) of the startle reflex can be disrupted by drugs that act as agonists at the serotonin (5-HT) 2A receptor, such as DOI, and this effect is blocked by drugs that inhibit 5-HT2A transmission. We tested the effects of systemic administration of PD149163, a neurotensin agonist, on DOI-induced disruption of PPI in Sprague-Dawley rats. PD149163 completely and dose dependently blocked the PPI deficits produced by DOI. These findings suggest that, in addition to their established ability to inhibit dopamine transmission, neurotensin agonists may also inhibit 5-HT2A transmission, a pharmacological feature associated with atypical antipsychotic drugs.

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Year:  2002        PMID： 12655309     DOI： 10.1038/sj.npp.1300083

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


  20 in total

1.  The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats.

Authors:  Elizabeth N Holly; Bree Ebrecht; Adam J Prus
Journal:  Eur Neuropsychopharmacol       Date:  2011-01-28       Impact factor: 4.600

Review 2.  The role of neurotensin in central nervous system pathophysiology: what is the evidence?

Authors:  Fannie St-Gelais; Claudia Jomphe; Louis-Eric Trudeau
Journal:  J Psychiatry Neurosci       Date:  2006-07       Impact factor: 6.186

Review 3.  Neurotensin agonists: potential in the treatment of schizophrenia.

Authors:  Mona Boules; Amanda Shaw; Paul Fredrickson; Elliott Richelson
Journal:  CNS Drugs       Date:  2007       Impact factor: 5.749

4.  Mutual independence of 5-HT(2) and α1 noradrenergic receptors in mediating deficits in sensorimotor gating.

Authors:  Sarah K Baisley; Katherine L Fallace; Abha K Rajbhandari; Vaishali P Bakshi
Journal:  Psychopharmacology (Berl)       Date:  2011-09-23       Impact factor: 4.530

5.  Association of Neurotensin receptor 1 gene polymorphisms with processing speed in healthy Chinese-Han subjects.

Authors:  Man Wang; Hui Ma; Ying-lin Huang; Gang Zhu; Jing-ping Zhao
Journal:  J Mol Neurosci       Date:  2014-08-27       Impact factor: 3.444

6.  The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance.

Authors:  David Feifel; Gilia Melendez; Rachel J Murray; Dan N Tina Tran; Michelle A Rullan; Paul D Shilling
Journal:  Psychopharmacology (Berl)       Date:  2008-06-21       Impact factor: 4.530

7.  Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats.

Authors:  Becky Kinkead; Feng Yan; Michael J Owens; Charles B Nemeroff
Journal:  Psychoneuroendocrinology       Date:  2007-12-21       Impact factor: 4.905

8.  Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonist.

Authors:  P D Shilling; G Melendez; K Priebe; E Richelson; D Feifel
Journal:  Psychopharmacology (Berl)       Date:  2004-09       Impact factor: 4.530

9.  The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle.

Authors:  Paul D Shilling; David Feifel
Journal:  Pharmacol Biochem Behav       Date:  2008-10       Impact factor: 3.533

10.  The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog.

Authors:  D Feifel; S Mexal; Gilia Melendez; Philip Y T Liu; Joseph R Goldenberg; Paul D Shilling
Journal:  Neuropsychopharmacology       Date:  2009-03-25       Impact factor: 7.853
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