| Literature DB >> 12654859 |
Yael Yuhas1, Abraham Weizman, Shai Ashkenazi.
Abstract
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.Entities:
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Year: 2003 PMID: 12654859 PMCID: PMC152059 DOI: 10.1128/IAI.71.4.2288-2291.2003
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441