Literature DB >> 12654845

Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning.

Irène Corthésy-Theulaz1, Blaise Corthésy, Daniel Bachmann, Dominique Velin, Jean-Pierre Kraehenbuhl.   

Abstract

The objective of this study was to examine the effect of breast-feeding by immunized dams on Helicobacter colonization in newborns. Urease-based immunization regimens failed to protect nursing pups against H. felis, whereas H. felis lysate-cholera toxin resulted in protection. This observation correlated with a high recognition of cell surface-expressed bacterial antigens by milk antibodies. Protection lasted until weaning, indicating that infection is maintained at undetectable levels by passive immunity but then resumes when breast-feeding stops.

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Year:  2003        PMID： 12654845      PMCID： PMC152048          DOI： 10.1128/IAI.71.4.2226-2229.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

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