Literature DB >> 1265479

Gating currents associated with sodium and calcium currents in an Aplysia neuron.

D J Adams, P W Gage.   

Abstract

In a voltage-clamped aplysia neuron (R15), depolarization beyond -30 millivolts produces an inward sodium current. Depolarization beyond -10 millivolts produces an additional inward calcium current with slower kinetics than the sodium current. When these ionic currents have been suppressed and capacitive currents subtracted out, a small outward displacement current can be seen with depolarizations beyond -30 millivolts. An additional, slower displacement current is seen with depolarizations beyond -10 millivolts. The currents have an exponential decay with an increase in rate per 10 degrees C increase in temperature of about 3 and are thought to be sodium and calcium gating currents.

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Year:  1976        PMID: 1265479     DOI: 10.1126/science.1265479

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  Calcium channels in the cell membrane.

Authors:  P G Kostyuk
Journal:  Neurosci Behav Physiol       Date:  1986 Sep-Oct

2.  Ionic currents in response to membrane depolarization in an Aplysia neurone.

Authors:  D J Adams; P W Gage
Journal:  J Physiol       Date:  1979-04       Impact factor: 5.182

3.  Asymmetry currents in the mammalian myelinated nerve.

Authors:  S Y Chiu
Journal:  J Physiol       Date:  1980-12       Impact factor: 5.182

4.  Sodium and calcium gating currents in an Aplysia neurone.

Authors:  D J Adams; P W Gage
Journal:  J Physiol       Date:  1979-06       Impact factor: 5.182

5.  Inactivation of delayed outward current in molluscan neurone somata.

Authors:  R W Aldrich; P A Getting; S H Thompson
Journal:  J Physiol       Date:  1979-06       Impact factor: 5.182

6.  Mechanism of frequency-dependent broadening of molluscan neurone soma spikes.

Authors:  R W Aldrich; P A Getting; S H Thompson
Journal:  J Physiol       Date:  1979-06       Impact factor: 5.182

7.  Characteristics of sodium and calcium conductance changes produced by membrane depolarization in an Aplysia neurone.

Authors:  D J Adams; P W Gage
Journal:  J Physiol       Date:  1979-04       Impact factor: 5.182

8.  Components of charge movement in rabbit skeletal muscle: the effect of tetracaine and nifedipine.

Authors:  G D Lamb
Journal:  J Physiol       Date:  1986-07       Impact factor: 5.182

9.  Activation kinetics of calcium currents in bull-frog sympathetic neurones.

Authors:  F Sala
Journal:  J Physiol       Date:  1991-06       Impact factor: 5.182

10.  Aequorin response facilitation and intracellular calcium accumulation in molluscan neurones.

Authors:  S J Smith; R S Zucker
Journal:  J Physiol       Date:  1980-03       Impact factor: 5.182

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