BACKGROUND AND AIM: This prospective study aimed to determine whether Doppler ultrasonography can represent the hepatic venous pressure gradient (HVPG) as an assessment of the severity of portal hypertension and the response to terlipressin, which reduces the portal pressure in liver cirrhosis. METHODS: The HVPG and the Doppler ultrasonographic parameters, such as the portal venous velocity and the splenic venous velocity, the pulsatility and the resistive index of the hepatic, splenic and renal arteries were measured in 138 patients with liver cirrhosis. The changes in the HVPG and the portal venous velocity after administering terlipressin were evaluated in 43 of the 138 patients. The patients who showed a reduction in the HVPG of more than 20% of the baseline were defined as responders to terlipressin. RESULTS: None of the Doppler ultrasonographic parameters correlated with the HVPG. Both the HVPG (28.0 +/- 19.8%) and the portal venous velocity (29.7 +/- 13.2%) showed a significant reduction after terlipressin administration. However, the portal venous velocity decreased significantly, not only in the responders (31.0 +/- 12.0%) but also in the non-responders (25.2 +/- 16.4%). CONCLUSIONS: Doppler ultrasonography does not represent the HVPG, and is therefore not suitable for replacing HVPG as a means of assessing the severity of portal hypertension and the response to drugs which reduce the portal pressure in liver cirrhosis. Copyright 2003 Blackwell Publishing Asia Pty Ltd
BACKGROUND AND AIM: This prospective study aimed to determine whether Doppler ultrasonography can represent the hepatic venous pressure gradient (HVPG) as an assessment of the severity of portal hypertension and the response to terlipressin, which reduces the portal pressure in liver cirrhosis. METHODS: The HVPG and the Doppler ultrasonographic parameters, such as the portal venous velocity and the splenic venous velocity, the pulsatility and the resistive index of the hepatic, splenic and renal arteries were measured in 138 patients with liver cirrhosis. The changes in the HVPG and the portal venous velocity after administering terlipressin were evaluated in 43 of the 138 patients. The patients who showed a reduction in the HVPG of more than 20% of the baseline were defined as responders to terlipressin. RESULTS: None of the Doppler ultrasonographic parameters correlated with the HVPG. Both the HVPG (28.0 +/- 19.8%) and the portal venous velocity (29.7 +/- 13.2%) showed a significant reduction after terlipressin administration. However, the portal venous velocity decreased significantly, not only in the responders (31.0 +/- 12.0%) but also in the non-responders (25.2 +/- 16.4%). CONCLUSIONS: Doppler ultrasonography does not represent the HVPG, and is therefore not suitable for replacing HVPG as a means of assessing the severity of portal hypertension and the response to drugs which reduce the portal pressure in liver cirrhosis. Copyright 2003 Blackwell Publishing Asia Pty Ltd
Authors: Ki Tae Suk; Moon Young Kim; Dong Hun Park; Kyu Hong Kim; Ki Won Jo; Jin Hon Hong; Jae Woo Kim; Hyun Soo Kim; Sang Ok Kwon; Soon Koo Baik Journal: Gut Liver Date: 2007-12-31 Impact factor: 4.519
Authors: John R Eisenbrey; Jaydev K Dave; Valgerdur G Halldorsdottir; Daniel A Merton; Cynthia Miller; José M Gonzalez; Priscilla Machado; Suhyun Park; Scott Dianis; Carl L Chalek; Christopher E Kim; Jeffrey P Baliff; Kai E Thomenius; Daniel B Brown; Victor Navarro; Flemming Forsberg Journal: Radiology Date: 2013-03-22 Impact factor: 11.105
Authors: Jayant A Talwalkar; Meng Yin; Sudhakar Venkatesh; Phillip J Rossman; Roger C Grimm; Armando Manduca; Anthony Romano; Patrick S Kamath; Richard L Ehman Journal: AJR Am J Roentgenol Date: 2009-07 Impact factor: 3.959