| Literature DB >> 12652295 |
Jian Hua Qi1, Quteba Ebrahem, Nina Moore, Gillian Murphy, Lena Claesson-Welsh, Mark Bond, Andrew Baker, Bela Anand-Apte.
Abstract
Tissue inhibitor of metalloproteinases-3 (TIMP3) is one of four members of a family of proteins that were originally classified according to their ability to inhibit matrix metalloproteinases (MMP). TIMP3, which encodes a potent angiogenesis inhibitor, is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. In this study we demonstrate the ability of TIMP3 to inhibit vascular endothelial factor (VEGF)-mediated angiogenesis and identify the potential mechanism by which this occurs: TIMP3 blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis. This property seems to be independent of its MMP-inhibitory activity, indicating a new function for this molecule.Entities:
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Year: 2003 PMID： 12652295 DOI： 10.1038/nm846
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440