Literature DB >> 12652156

Role of nitric oxide in matrix remodeling in diabetes and heart failure.

Suresh C Tyagi1, Melvin R Hayden.   

Abstract

Accumulation of oxidized-matrix between the endothelium and myocytes is associated with endocardial endothelial (EE) dysfunction in diabetes and heart failure. High levels of circulating homocysteine (Hcy) have been demonstrated in diabetes mellitus (DM). These high levels of Hcy (hyperhomocysteinemia, HHcy) have a negative correlation with peroxisome proliferator activated receptor (PPAR) expression. Studies have demonstrated that Hcy decreases bioavailability of endothelial nitric oxide (eNO), generates nitrotyrosine, and activates latent matrix metalloproteinase (MMP), instigating EE dysfunction. PPAR ligands ameliorate endothelial dysfunction and DM. In addition Hcy competes with PPAR ligands. The understanding of molecular, cellular, and extracellular mechanisms by which Hcy amplifies DM will have therapeutic ramifications for diabetic cardiomyopathy.

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Year:  2003        PMID： 12652156     DOI： 10.1023/a:1022138803293

Source DB:  PubMed          Journal:  Heart Fail Rev        ISSN： 1382-4147            Impact factor:   4.214


  62 in total

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Journal:  Am J Hypertens       Date:  2000-01       Impact factor: 2.689

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Journal:  Recent Prog Horm Res       Date:  2001

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Journal:  Am J Anat       Date:  1988-07

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Journal:  Circulation       Date:  2001-09-04       Impact factor: 29.690

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Journal:  Circulation       Date:  2001-10-02       Impact factor: 29.690

8.  Ultrasonic videodensitometric analysis in type 1 diabetic myocardium.

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Journal:  Coron Artery Dis       Date:  1996-12       Impact factor: 1.439

9.  Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.

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Journal:  Nat Med       Date:  1998-08       Impact factor: 53.440

10.  The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in newborn rats.

Authors:  A Radomski; G Sawicki; D M Olson; M W Radomski
Journal:  Br J Pharmacol       Date:  1998-12       Impact factor: 8.739
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  12 in total

1.  An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.

Authors:  Mathieu Nadeau; Romain O Georges; Brigitte Laforest; Abir Yamak; Chantal Lefebvre; Janie Beauregard; Pierre Paradis; Benoit G Bruneau; Gregor Andelfinger; Mona Nemer
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

2.  Diabetic peripheral neuropathy: an update on pathogenesis and management.

Authors:  Betul M Gundogdu
Journal:  Curr Neurol Neurosci Rep       Date:  2006-01       Impact factor: 5.081

Review 3.  Arrhythmia and neuronal/endothelial myocyte uncoupling in hyperhomocysteinemia.

Authors:  Dorothea Rosenberger; Karni S Moshal; Ganesh K Kartha; Neetu Tyagi; Utpal Sen; David Lominadze; Claudio Maldonado; Andrew M Roberts; Suresh C Tyagi
Journal:  Arch Physiol Biochem       Date:  2006 Oct-Dec       Impact factor: 4.076

Review 4.  Role of estrogen in diastolic dysfunction.

Authors:  Zhuo Zhao; Hao Wang; Jewell A Jessup; Sarah H Lindsey; Mark C Chappell; Leanne Groban
Journal:  Am J Physiol Heart Circ Physiol       Date:  2014-01-10       Impact factor: 4.733

5.  Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras.

Authors:  Renu A Kowluru
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-03-10       Impact factor: 4.799

6.  Ultrastructure Study of Transgenic Ren2 Rat Aorta - Part 1: Endothelium and Intima.

Authors:  Melvin R Hayden; Javad Habibi; Tejaswini Joginpally; Poorna R Karuparthi; James R Sowers
Journal:  Cardiorenal Med       Date:  2012-01-27       Impact factor: 2.041

7.  Activation of the poly(ADP-ribose) polymerase pathway in human heart failure.

Authors:  Andrea Molnár; Attila Tóth; Zsolt Bagi; Zoltán Papp; István Edes; Miklós Vaszily; Zoltán Galajda; Julius Gy Papp; András Varró; Viktória Szüts; Zsombor Lacza; Domokos Gerö; Csaba Szabó
Journal:  Mol Med       Date:  2006 Jul-Aug       Impact factor: 6.354

8.  Dysregulation of matrix metalloproteinases and their tissue inhibitors is related to abnormality of left ventricular geometry and function in streptozotocin-induced diabetic minipigs.

Authors:  Lin Lu; Qi Zhang; Li Jin Pu; Wen Hui Peng; Xiao Xiang Yan; Lin Jie Wang; Qiu Jing Chen; Zheng Bing Zhu; Jean-Baptiste Michel; Wei Feng Shen
Journal:  Int J Exp Pathol       Date:  2008-04       Impact factor: 1.925

9.  Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.

Authors:  Julia M Santos; Shikha Tewari; Jonathan Y Lin; Renu A Kowluru
Journal:  Biochem Biophys Res Commun       Date:  2013-07-24       Impact factor: 3.575

10.  Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice.

Authors:  Soumi Kundu; Munish Kumar; Utpal Sen; Paras K Mishra; Neetu Tyagi; Naira Metreveli; David Lominadze; Walter Rodriguez; Suresh C Tyagi
Journal:  J Cell Biochem       Date:  2009-01-01       Impact factor: 4.429
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