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Literature DB >> 12651223

The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer.

Penny L Jeffery¹, Adrian C Herington, Lisa K Chopin.

Abstract

Ghrelin is a recently identified 28 amino acid peptide capable of stimulating pituitary growth hormone release in humans. The actions of ghrelin are mediated via the naturally occurring ghrelin receptor, also known as the growth hormone secretagogue receptor (GHS-R). Ghrelin and its receptors are now being recognized as components of the growth hormone axis and are therefore potentially involved in tissue growth and development. As is the case for other members of this axis, evidence is rapidly emerging to indicate that ghrelin/GHS-R may play an important autocrine/paracrine role in some cancers. This review highlights the evidence for the expression, regulation and potential functional role of ghrelin and its receptor in hormone-dependent cancers, such as prostate and breast cancer.

Entities: Chemical Disease Gene Species

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Year: 2003 PMID： 12651223 DOI： 10.1016/s1359-6101(02)00089-8

Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638

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Cited

20 in total

Review 1. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.

Authors: Dennis D Taub; William J Murphy; Dan L Longo
Journal: Curr Opin Pharmacol Date: 2010-06-04 Impact factor: 5.547

2. Ghrelin immunoexpression in pituitary adenomas.

Authors: Fabio Rotondo; Michael Cusimano; Bernd W Scheithauer; Angelo Rotondo; Luis V Syro; Kalman Kovacs
Journal: Pituitary Date: 2011-12 Impact factor: 4.107

3. Development of a [⁶⁸Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a).

Authors: C L Charron; M S McFarland; S Dhanvantari; L G Luyt
Journal: Medchemcomm Date: 2018-09-17 Impact factor: 3.597

4. Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.

Authors: Daniele Campa; Barbara Pardini; Alessio Naccarati; Ludmila Vodickova; Jan Novotny; Verena Steinke; Nils Rahner; Elke Holinski-Feder; Monika Morak; Hans K Schackert; Heike Görgens; Judith Kötting; Beate Betz; Matthias Kloor; Christoph Engel; Reinhard Büttner; Peter Propping; Asta Försti; Kari Hemminki; Roberto Barale; Pavel Vodicka; Federico Canzian
Journal: BMC Gastroenterol Date: 2010-09-28 Impact factor: 3.067

Review 5. Is there a role of ghrelin in preventing catabolism?

Authors: J A M J L Janssen; A J van der Lely; S W J Lamberts
Journal: J Endocrinol Invest Date: 2004-04 Impact factor: 4.256

6. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation.

Authors: Jonathon T Hill; Teresa L Mastracci; Carol Vinton; Michelle L Doyle; Keith R Anderson; Zoe L Loomis; Jessica M Schrunk; Angela D Minic; Kamalaveni R Prabakar; Alberto Pugliese; Yuxian Sun; Roy G Smith; Lori Sussel
Journal: Regul Pept Date: 2009-03-05

7. Ghrelin promotes oral tumor cell proliferation by modifying GLUT1 expression.

Authors: Dominik Kraus; Jan Reckenbeil; Matthias Wenghoefer; Helmut Stark; Matthias Frentzen; Jean-Pierre Allam; Natalija Novak; Stilla Frede; Werner Götz; Rainer Probstmeier; Rainer Meyer; Jochen Winter
Journal: Cell Mol Life Sci Date: 2015-09-25 Impact factor: 9.261

The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer.

Review 1. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.

2. Ghrelin immunoexpression in pituitary adenomas.

3. Development of a [⁶⁸Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a).

4. Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.

Review 5. Is there a role of ghrelin in preventing catabolism?

6. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation.

7. Ghrelin promotes oral tumor cell proliferation by modifying GLUT1 expression.

Review 8. Ghrelin in neuroendocrine organs and tumours.

9. Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.

Review 10. Obesity and colorectal cancer: role of adipokines in tumor initiation and progression.

The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer.

Review 1. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.

2. Ghrelin immunoexpression in pituitary adenomas.

3. Development of a [68Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a).

4. Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study.

Review 5. Is there a role of ghrelin in preventing catabolism?

6. Ghrelin is dispensable for embryonic pancreatic islet development and differentiation.

7. Ghrelin promotes oral tumor cell proliferation by modifying GLUT1 expression.

Review 8. Ghrelin in neuroendocrine organs and tumours.

9. Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.

Review 10. Obesity and colorectal cancer: role of adipokines in tumor initiation and progression.

3. Development of a [⁶⁸Ga]-ghrelin analogue for PET imaging of the ghrelin receptor (GHS-R1a).