Literature DB >> 12650994

Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat.

Dave Albeck1, Michael H Mesches, Sonya Juthberg, Michael Browning, Paula C Bickford, Gregory M Rose, A-Ch Granholm.   

Abstract

Alzheimer's disease and normal aging may impair retrograde transport of nerve growth factor (NGF) from cortical areas to basal forebrain cholinergic neurons. We demonstrate a relationship between performance in a spatial reference memory task and NGF distribution in the aged rat brain. In addition, exogenous NGF restored endogenous NGF distribution in cognitively impaired aged rats. These data suggest that NGF administration restores utilization of endogenous growth factor in the brain of cognitively impaired aged rats.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12650994     DOI： 10.1016/s0006-8993(03)02272-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences.

Authors:  Nancyellen C de Fiebre; Nathalie Sumien; Michael J Forster; Christopher M de Fiebre
Journal:  Age (Dordr)       Date:  2006-12-05

2.  Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging.

Authors:  H A Boger; P Mannangatti; D J Samuvel; A J Saylor; T S Bender; J F McGinty; A M Fortress; V Zaman; P Huang; L D Middaugh; P K Randall; L D Jayanthi; B Rohrer; K L Helke; A-C Granholm; S Ramamoorthy
Journal:  Genes Brain Behav       Date:  2010-10-19       Impact factor: 3.449

3.  Leverpress escape/avoidance training increases neurotrophin levels in rat brain.

Authors:  David S Albeck; Kevin D Beck; Ling-Hsuan Kung; Kazuhiro Sano; Francis X Brennan
Journal:  Integr Physiol Behav Sci       Date:  2005 Jan-Mar

4.  Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF.

Authors:  Ofelia M Littrell; Ann-Charlotte Granholm; Greg A Gerhardt; Heather A Boger
Journal:  Pharmacol Biochem Behav       Date:  2013-01-02       Impact factor: 3.533

5.  ERK-mediated NGF signaling in the rat septo-hippocampal pathway diminishes with age.

Authors:  Brice J Williams; Heather A Bimonte-Nelson; Ann-Charlotte Granholm-Bentley
Journal:  Psychopharmacology (Berl)       Date:  2006-08-17       Impact factor: 4.530

Review 6.  Neurotrophic factors in neurodegenerative disorders : potential for therapy.

Authors:  Fabio Fumagalli; Raffaella Molteni; Francesca Calabrese; Paola Francesca Maj; Giorgio Racagni; Marco Andrea Riva
Journal:  CNS Drugs       Date:  2008       Impact factor: 5.749

7.  Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"?

Authors:  Heather A Bimonte-Nelson; Ann-Charlotte E Granholm; Matthew E Nelson; Alfred B Moore
Journal:  Exp Aging Res       Date:  2008 Jan-Mar       Impact factor: 1.645
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.