Literature DB >> 12650988

Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity.

Sayaka Tokunaga1, Janelle R McDaniel, A Leslie Morrow, Douglas B Matthews.   

Abstract

We investigated the effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity. Both agents produced significant reductions in spontaneous firing rate of hippocampal pyramidal neurons at a medium and high doses. Furthermore, blockade of allopregnanolone biosynthesis by preadministration of finasteride, a 5alpha-reductase blocker, prevented ethanol-induced inhibition on hippocampal pyramidal neural activity. The results further demonstrate similar effects of allopregnanolone and ethanol on hippocampal neurophysiology and that allopregnanolone plays a key role in producing ethanol-induced inhibition of hippocampal neural activity.

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Year:  2003        PMID： 12650988     DOI： 10.1016/s0006-8993(02)04266-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  14 in total

1.  Ethanol alters local cellular levels of (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) independent of the adrenals in subcortical brain regions.

Authors:  Jason B Cook; Stephanie M Nelli; Mackenzie R Neighbors; Danielle H Morrow; Todd K O'Buckley; Antoniette M Maldonado-Devincci; A Leslie Morrow
Journal:  Neuropsychopharmacology       Date:  2014-02-25       Impact factor: 7.853

2.  Behavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning.

Authors:  Jesse D Cushman; Melissa D Moore; Nate S Jacobs; Richard W Olsen; Michael S Fanselow
Journal:  Alcohol Clin Exp Res       Date:  2011-09-21       Impact factor: 3.455

Review 3.  Acute and chronic effects of ethanol on learning-related synaptic plasticity.

Authors:  Charles F Zorumski; Steven Mennerick; Yukitoshi Izumi
Journal:  Alcohol       Date:  2013-12-16       Impact factor: 2.405

4.  Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity.

Authors:  Charles E Roselli; Timothy J Finn; Sean M Ronnekleiv-Kelly; Michelle A Tanchuck; Katherine R Kaufman; Deborah A Finn
Journal:  Alcohol       Date:  2011-09-14       Impact factor: 2.405

5.  Behavioral effects of ethanol in cerebellum are age dependent: potential system and molecular mechanisms.

Authors:  Candice E Van Skike; Paolo Botta; Vivien S Chin; Sayaka Tokunaga; Janelle M McDaniel; Jacob Venard; Jaime L Diaz-Granados; C Fernando Valenzuela; Douglas B Matthews
Journal:  Alcohol Clin Exp Res       Date:  2010-09-22       Impact factor: 3.455

6.  Basis of the gabamimetic profile of ethanol.

Authors:  G R Breese; H E Criswell; M Carta; P D Dodson; H J Hanchar; R T Khisti; M Mameli; Z Ming; A L Morrow; R W Olsen; T S Otis; L H Parsons; S N Penland; M Roberto; G R Siggins; C F Valenzuela; M Wallner
Journal:  Alcohol Clin Exp Res       Date:  2006-04       Impact factor: 3.455

7.  Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.

Authors:  Kevin N Boyd; Sandeep Kumar; Todd K O'Buckley; Patrizia Porcu; A Leslie Morrow
Journal:  J Neurochem       Date:  2009-11-26       Impact factor: 5.372

8.  Ethanol administration produces divergent changes in GABAergic neuroactive steroid immunohistochemistry in the rat brain.

Authors:  Jason B Cook; Ana Maria G Dumitru; Todd K O'Buckley; A Leslie Morrow
Journal:  Alcohol Clin Exp Res       Date:  2013-07-26       Impact factor: 3.455

9.  Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene.

Authors:  Michelle A Tanchuck-Nipper; Matthew M Ford; Anna Hertzberg; Amy Beadles-Bohling; Debra K Cozzoli; Deborah A Finn
Journal:  Behav Genet       Date:  2014-10-31       Impact factor: 2.805

10.  Failure of acute ethanol administration to alter cerebrocortical and hippocampal allopregnanolone levels in C57BL/6J and DBA/2J mice.

Authors:  Patrizia Porcu; Andrea Locci; Francesca Santoru; Roberta Berretti; A Leslie Morrow; Alessandra Concas
Journal:  Alcohol Clin Exp Res       Date:  2014-01-15       Impact factor: 3.455
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