Literature DB >> 12650856

Endogenous gamma-hydroxybutyric acid is in the rat, mouse and human gastrointestinal tract.

Luciano Tedeschi1, Mauro A M Carai, Giampietro Frison, Donata Favretto, Giancarlo Colombo, Santo Davide Ferrara, Gian Luigi Gessa.   

Abstract

By using Gas Chromatography-Mass Spectrometry high concentrations of endogenous gamma-hydroxybutyric acid (GHB) have been demonstrated in the rat and mouse gastrointestinal tract, including stomach, small intestine and colon-rectum. GHB concentrations were many folds higher than those present in the brain. High GHB concentrations have been also found in the human operatory specimen of sigmoid colon. Since GHB administration has been found to modify gastrointestinal motility via GABA(B) receptors, the present results suggest that endogenous GHB might be involved in the GABA(B) receptor-mediated control of gastrointestinal function.

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Year:  2003        PMID： 12650856     DOI： 10.1016/s0024-3205(03)00143-7

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  6 in total

1.  Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid.

Authors:  Melanie A Felmlee; Samuel A Roiko; Bridget L Morse; Marilyn E Morris
Journal:  J Pharmacol Exp Ther       Date:  2010-03-09       Impact factor: 4.030

2.  Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid.

Authors:  Melanie A Felmlee; Wojciech Krzyzanski; Bridget L Morse; Marilyn E Morris
Journal:  AAPS J       Date:  2011-03-09       Impact factor: 4.009

3.  The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition.

Authors:  Dapeng Cui; Marilyn E Morris
Journal:  Drug Metab Dispos       Date:  2009-04-23       Impact factor: 3.922

4.  Effects of L-lactate and D-mannitol on gamma-hydroxybutyrate toxicokinetics and toxicodynamics in rats.

Authors:  Qi Wang; Xiaodong Wang; Marilyn E Morris
Journal:  Drug Metab Dispos       Date:  2008-08-21       Impact factor: 3.922

5.  Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome.

Authors:  Jennifer S Labus; Emily B Hollister; Jonathan Jacobs; Kyleigh Kirbach; Numan Oezguen; Arpana Gupta; Jonathan Acosta; Ruth Ann Luna; Kjersti Aagaard; James Versalovic; Tor Savidge; Elaine Hsiao; Kirsten Tillisch; Emeran A Mayer
Journal:  Microbiome       Date:  2017-05-01       Impact factor: 14.650

6.  Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.

Authors:  Jie Han; Dakota Jackson; Janette Holm; Kevin Turner; Paula Ashcraft; Xuan Wang; Beth Cook; Erland Arning; Robert M Genta; K Venuprasad; Rhonda F Souza; Lawrence Sweetman; Arianne L Theiss
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-16       Impact factor: 11.205
  6 in total

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