Literature DB >> 12646320

The expression and localization of heme oxygenase in the adult guinea pig cochlea.

Kojiro Watanabe1, Takeshi Oshima, Toshimitsu Kobayashi, Katsuhisa Ikeda.   

Abstract

Reverse transcription-polymerase chain reaction demonstrated the expression of heme oxygenase-1 and heme oxygenase-2 (HO-2) mRNA in the cochlea, but the former was considered to be much lower than the latter. The HO-2-like immunoreactivity was observed mainly in supporting cells in the organ of Corti and in the spiral ganglion cells. However, in the vascular walls of the cochlea little immunoreactivity was detected. These results suggest that HO-2 is involved in the auditory neurotransmission and micromechanics of the organ of Corti.

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Year:  2003        PMID: 12646320     DOI: 10.1016/s0006-8993(02)04209-9

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  2 in total

1.  Audiological and electrocochleography findings in hearing-impaired children with connexin 26 mutations and otoacoustic emissions.

Authors:  Rosamaria Santarelli; Elona Cama; Pietro Scimemi; Erica Dal Monte; Elisabetta Genovese; Edoardo Arslan
Journal:  Eur Arch Otorhinolaryngol       Date:  2007-08-14       Impact factor: 2.503

2.  [Influence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat].

Authors:  B Mazurek; C Rheinländer; F-U Fuchs; N Amarjargal; R-J Kuban; U Ungethüm; H Haupt; T Kietzmann; J Gross
Journal:  HNO       Date:  2006-09       Impact factor: 1.284

  2 in total

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