Literature DB >> 12646149

Fragile sites: breaking up over a slowdown.

Karlene A Cimprich1.   

Abstract

Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.

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Year:  2003        PMID： 12646149     DOI： 10.1016/s0960-9822(03)00158-1

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  22 in total

1.  Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Authors:  Tony S Byun; Marcin Pacek; Muh-ching Yee; Johannes C Walter; Karlene A Cimprich
Journal:  Genes Dev       Date:  2005-04-15       Impact factor: 11.361

2.  Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.

Authors:  Patrick J Lupardus; Christopher Van; Karlene A Cimprich
Journal:  Methods       Date:  2007-02       Impact factor: 3.608

3.  Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.

Authors:  Patrick J Lupardus; Karlene A Cimprich
Journal:  Mol Biol Cell       Date:  2006-01-25       Impact factor: 4.138

4.  Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.

Authors:  Min Zhu; Robert S Weiss
Journal:  Mol Biol Cell       Date:  2007-01-10       Impact factor: 4.138

5.  A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies.

Authors:  Anthony L Gotter; Manjunath A Nimmakayalu; G Reza Jalali; April M Hacker; Jacob Vorstman; Danielle Conforto Duffy; Livija Medne; Beverly S Emanuel
Journal:  Genome Res       Date:  2007-03-09       Impact factor: 9.043

6.  Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.

Authors:  Peter S Levitt; Min Zhu; Amy Cassano; Stephanie A Yazinski; Houchun Liu; Joshua Darfler; Rachel M Peters; Robert S Weiss
Journal:  Mol Cell Biol       Date:  2007-01-12       Impact factor: 4.272

7.  DNA Damage Response in Xenopus laevis Cell-Free Extracts.

Authors:  Tomas Aparicio Casado; Jean Gautier
Journal:  Methods Mol Biol       Date:  2021

8.  One in four individuals of African-American ancestry harbors a 5.5kb deletion at chromosome 11q13.1.

Authors:  Kayvan Zainabadi; Anuja V Jain; Frank X Donovan; David Elashoff; Nagesh P Rao; Vundavalli V Murty; Settara C Chandrasekharappa; Eri S Srivatsan
Journal:  Genomics       Date:  2014-01-10       Impact factor: 5.736

9.  The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

Authors:  Sinny Delacroix; Jill M Wagner; Masahiko Kobayashi; Ken-ichi Yamamoto; Larry M Karnitz
Journal:  Genes Dev       Date:  2007-06-15       Impact factor: 11.361

10.  microRNA-based cancer cell reprogramming technology.

Authors:  Shimpei Nishikawa; Hideshi Ishii; Naotsugu Haraguchi; Yoshihiro Kano; Takahito Fukusumi; Katsuya Ohta; Miyuki Ozaki; Dyah Laksmi Dewi; Daisuke Sakai; Taroh Satoh; Hiroaki Nagano; Yuichiro Doki; Masaki Mori
Journal:  Exp Ther Med       Date:  2012-04-23       Impact factor: 2.447
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