| Literature DB >> 12646029 |
Vincent Guerlavais1, Damien Boeglin, Delphine Mousseaux, Catherine Oiry, Annie Heitz, Romano Deghenghi, Vittorio Locatelli, Antonio Torsello, Corrado Ghé, Filomena Catapano, Giampiero Muccioli, Jean-Claude Galleyrand, Jean-Alain Fehrentz, Jean Martinez.
Abstract
New growth hormone secretagogue (GHS) analogues were synthesized and evaluated for growth hormone releasing activity. This series derived from EP-51389 is based on a gem-diamino structure. Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(d)-Trp-(d)-gTrp-formyl) showed high potency in these tests and was selected for clinical studies.(1)Entities:
Mesh：
Substances：
Year: 2003 PMID： 12646029 DOI： 10.1021/jm020985q
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446