Literature DB >> 12645018

Novel carboranyl C-glycosides for the treatment of cancer by boron neutron capture therapy.

Lutz F Tietze1, Ulrich Griesbach, Ingrid Schuberth, Ulrich Bothe, Alberto Marra, Alessandro Dondoni.   

Abstract

The synthesis of the novel unprotected carboranyl C-glycosides 2 and 20-24 starting from ethynyl C-glycosides 1, 5-8, 10, and 13 is described. The new compounds are highly water-soluble and display only a very low cytotoxicity, which makes them promising candidates for use in boron neutron capture therapy for the treatment of cancer.

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Year:  2003        PMID： 12645018     DOI： 10.1002/chem.200390148

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  4 in total

Review 1.  N3-substituted thymidine bioconjugates for cancer therapy and imaging.

Authors:  Ahmed Khalil; Keisuke Ishita; Tehane Ali; Werner Tjarks
Journal:  Future Med Chem       Date:  2013-04       Impact factor: 3.808

2.  Cross-metathesis reaction of α- and β-vinyl C-glycosides with alkenes.

Authors:  Ivan Šnajdr; Kamil Parkan; Filip Hessler; Martin Kotora
Journal:  Beilstein J Org Chem       Date:  2015-08-10       Impact factor: 2.883

3.  Preparation of dendritic carboranyl glycoconjugates as potential anticancer therapeutics.

Authors:  Biswa Ranjan Swain; Chandra Sekhara Mahanta; Bibhuti Bhusan Jena; Swaraj Kumar Beriha; Bismita Nayak; Rashmirekha Satapathy; Barada P Dash
Journal:  RSC Adv       Date:  2020-09-18       Impact factor: 4.036

4.  Addressing the Biochemical Foundations of a Glucose-Based "Trojan Horse"-Strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment.

Authors:  Jelena Matović; Juulia Järvinen; Helena C Bland; Iris K Sokka; Surachet Imlimthan; Ruth Mateu Ferrando; Kristiina M Huttunen; Juri Timonen; Sirpa Peräniemi; Olli Aitio; Anu J Airaksinen; Mirkka Sarparanta; Mikael P Johansson; Jarkko Rautio; Filip S Ekholm
Journal:  Mol Pharm       Date:  2020-09-02       Impact factor: 4.939
  4 in total

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