| Literature DB >> 12643942 |
W Cameron Black1, Christine Brideau, Chi Chung Chan, Stella Charleson, Wanda Cromlish, Robert Gordon, Erich L Grimm, Gregory Hughes, Serge Leger, Chun Sing Li, Denis Riendeau, Michel Thérien, Zhaoyin Wang, Li Jing Xu, Petpiboon Prasit.
Abstract
The introduction of a hydroxyl group into the 5-position of the diaryl furanone system provides highly selective inhibitors of cyclooxygenase-2. These molecules can be converted into their sodium salts which are water soluble, facilitating intravenous formulation. These salts show excellent potency in rat models of pain, fever and inflammation.Entities:
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Year: 2003 PMID： 12643942 DOI： 10.1016/s0960-894x(03)00046-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823