Literature DB >> 12643940

Structure-activity relationships studies of the anti-angiogenic activities of linomide.

Jiandong Shi1, Zili Xiao, Michael A Ihnat, Chandrashekhar Kamat, Bulbul Pandit, Zhigen Hu, Pui-Kai Li.   

Abstract

The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.

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Year:  2003        PMID： 12643940     DOI： 10.1016/s0960-894x(03)00047-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo.

Authors:  Juan R Rodrigues; Jaime Charris; Rosa Ferrer; Neira Gamboa; Jorge Angel; Bianca Nitzsche; Michael Hoepfner; Michael Lein; Klaus Jung; Claudia Abramjuk
Journal:  Invest New Drugs       Date:  2011-07-12       Impact factor: 3.850

2.  Design, synthesis, graph theoretical analysis and molecular modelling studies of novel substituted quinoline analogues as promising anti-breast cancer agents.

Authors:  Prachita Gauns Dessai; Shivani Prabhu Dessai; Renuka Dabholkar; Padmashree Pednekar; Sahili Naik; Shivlingrao Mamledesai; Murugananthan Gopal; Parasuraman Pavadai; Banoth Karan Kumar; Sankaranarayanan Murugesan; Sachin Chandavarkar; Panneerselvam Theivendren; Kunjiappan Selvaraj
Journal:  Mol Divers       Date:  2022-08-17       Impact factor: 3.364

3.  A new synthetic approach to functionalize pyrimido[4,5-b]quinoline-2,4(1H,3H)-diones via a three-component one-pot reaction.

Authors:  Karen Aknin; Stéphanie Desbène-Finck; Philippe Helissey; Sylviane Giorgi-Renault
Journal:  Mol Divers       Date:  2009-05-19       Impact factor: 2.943

4.  One-pot copper-catalyzed three-component reaction: a modular approach to functionalized 2-quinolones.

Authors:  Ah Reum Kim; Hee Nam Lim
Journal:  RSC Adv       Date:  2020-02-24       Impact factor: 4.036

5.  One-Pot Three-Component Synthesis of Novel Diethyl((2-oxo-1,2-dihydroquinolin-3-yl)(arylamino)methyl)phosphonate as Potential Anticancer Agents.

Authors:  Yi-Lin Fang; Zhi-Lin Wu; Meng-Wu Xiao; Yu-Ting Tang; Kang-Ming Li; Jiao Ye; Jian-Nan Xiang; Ai-Xi Hu
Journal:  Int J Mol Sci       Date:  2016-04-29       Impact factor: 5.923
  5 in total

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