| Literature DB >> 12643919 |
John E Tellew1, Rose Ann F Baska, Sophie M Beyer, Kenneth E Carlson, Lyndon A Cornelius, Leena Fadnis, Zhengxiang Gu, Bridgette L Kunst, Mark C Kowala, Hossain Monshizadegan, Natesan Murugesan, Carol S Ryan, Maria T Valentine, Yifan Yang, John E Macor.
Abstract
A series of 4'-[(imidazol-1-yl)methyl]biphenylsulfonamides has potent antagonist activity against both angiotensin II AT(1) and endothelin ET(A) receptors. Such dual-acting antagonists could have utility in the treatment of hypertension, heart failure, and other cardiovascular diseases in a broad patient population. Certain compounds in the present series are orally active in a rat model of angiotensin II-mediated hypertension.Entities:
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Year: 2003 PMID： 12643919 DOI： 10.1016/s0960-894x(03)00018-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823