| Literature DB >> 12643911 |
Montserrat Rodriguez1, Danièle Bonnet-Delpon, Jean Pierre Bégué, Anne Robert, Bernard Meunier.
Abstract
The alkylating properties of two artemisinin derivatives bearing a trifluoromethyl substituent at C10 were evaluated toward manganese(II) tetraphenylporphyrin, considered as a heme model. Chlorin-type covalent adducts were obtained by alkylation of the porphyrin ring by C-centered radicals derived from reductive activation of the peroxide function of the drugs.Entities:
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Year: 2003 PMID： 12643911 DOI： 10.1016/s0960-894x(03)00076-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823