Literature DB >> 12643908

Anastatins A and B, new skeletal flavonoids with hepatoprotective activities from the desert plant Anastatica hierochuntica.

Masayuki Yoshikawa1, Fengming Xu, Toshio Morikawa, Kiyofumi Ninomiya, Hisashi Matsuda.   

Abstract

New skeletal flavonoids, anastatins A and B, were isolated from the methanolic extract of an Egyptian medicinal herb, the whole plants of Anastatica hierochuntica. Their flavanone structures having a benzofuran moiety were determined on the basis of chemical and physicochemical evidence. Anastatins A and B were found to show hepatoprotective effects on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes and their activities were stronger than those of related flavonoids and commercial silybin.

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Year:  2003        PMID： 12643908     DOI： 10.1016/s0960-894x(03)00088-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Multiple Skeletal Anomalies of Sprague Dawley Rats following Prenatal Exposure to Anastatica hierochuntica, as Delineated by a Modified Double-Staining Method.

Authors:  Siti Rosmani Md Zin; Mohammed Abdullah Alshawsh; Zahurin Mohamed
Journal:  Children (Basel)       Date:  2022-05-23

2.  Hepatoprotective Limonoids from Andiroba (Carapa guianensis).

Authors:  Kiyofumi Ninomiya; Seiya Miyazawa; Kaiten Ozeki; Natsuko Matsuo; Osamu Muraoka; Takashi Kikuchi; Takeshi Yamada; Reiko Tanaka; Toshio Morikawa
Journal:  Int J Mol Sci       Date:  2016-04-19       Impact factor: 5.923

3.  Antioxidant activities of anastatin A & B derivatives and compound 38c's protective effect in a mouse model of CCl4-induced acute liver injury.

Authors:  Cen Xiang; Menglin Cao; Ai Miao; Feng Gao; Xuzhe Li; Guojun Pan; Wenqiang Zhang; Yongmin Zhang; Peng Yu; Yuou Teng
Journal:  RSC Adv       Date:  2020-04-14       Impact factor: 4.036

4.  Comparison between effects of different doses of Melissa officinalis and atorvastatin on the activity of liver enzymes in hypercholesterolemia rats.

Authors:  Ali Zarei; Saeed Changizi Ashtiyani; Soheila Taheri; Fateme Rasekh
Journal:  Avicenna J Phytomed       Date:  2014-01
  4 in total

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