AIMS: The extent to which left ventricular (LV) mass, an independent cardiovascular risk factor, is determined by genetic factors is unclear. The aim of this study was to assess the heritability of LV mass and its association with three potential candidate genes. METHODS: A population-based adult twin study model was utilized. Echocardiographic assessment of LV mass was performed in 110 twin pairs (mean age 55.9+/-10.9 years). An estimate of genetic determination, heritability, was calculated for the main echocardiographic parameters. The cohort were genotyped for the G-protein beta-3, aldosterone synthase, and beta-1 adrenoceptor genes. RESULTS: The intra-class correlation coefficients for LV mass were 0.69 for monozygotic (r-MZ) twins and 0.32 for dizygotic (r-DZ) twins, P=0.008 (heritability estimate of 0.69). This pattern persisted following correction for known confounding factors. Within-pair differences in the monozygotic, discordant and concordant dizygotic twins showed no differences for the three genes with respect to left ventricular wall thickness or mass. There was a non-significant trend towards a relationship between LV mass and the beta-1 adrenoceptor genotype. CONCLUSION: Within a normal population left ventricular mass has a significant genetic determination. Further investigation of potential candidate genes is required.
AIMS: The extent to which left ventricular (LV) mass, an independent cardiovascular risk factor, is determined by genetic factors is unclear. The aim of this study was to assess the heritability of LV mass and its association with three potential candidate genes. METHODS: A population-based adult twin study model was utilized. Echocardiographic assessment of LV mass was performed in 110 twin pairs (mean age 55.9+/-10.9 years). An estimate of genetic determination, heritability, was calculated for the main echocardiographic parameters. The cohort were genotyped for the G-protein beta-3, aldosterone synthase, and beta-1 adrenoceptor genes. RESULTS: The intra-class correlation coefficients for LV mass were 0.69 for monozygotic (r-MZ) twins and 0.32 for dizygotic (r-DZ) twins, P=0.008 (heritability estimate of 0.69). This pattern persisted following correction for known confounding factors. Within-pair differences in the monozygotic, discordant and concordant dizygotic twins showed no differences for the three genes with respect to left ventricular wall thickness or mass. There was a non-significant trend towards a relationship between LV mass and the beta-1 adrenoceptor genotype. CONCLUSION: Within a normal population left ventricular mass has a significant genetic determination. Further investigation of potential candidate genes is required.
Authors: J Yeboah; J R Crouse; D A Bluemke; J A C Lima; J F Polak; G L Burke; D M Herrington Journal: J Hum Hypertens Date: 2010-03-18 Impact factor: 3.012
Authors: Suh-Hang Hank Juo; Marco R Di Tullio; Hsiu-Fen Lin; Tanja Rundek; Bernadette Boden-Albala; Shunichi Homma; Ralph L Sacco Journal: J Am Coll Cardiol Date: 2005-08-16 Impact factor: 24.094
Authors: Aldo M Costa; Luiza Breitenfeld; António J Silva; Ana Pereira; Mikel Izquierdo; Mário C Marques Journal: Sports Med Date: 2012-06-01 Impact factor: 11.136
Authors: Hélène Choquet; Khanh K Thai; Chen Jiang; Dilrini K Ranatunga; Thomas J Hoffmann; Alan S Go; Alistair C Lindsay; Margaret G Ehm; Dawn M Waterworth; Neil Risch; Catherine Schaefer Journal: Circ Genom Precis Med Date: 2020-06-30
Authors: Sara Mutikainen; Alfredo Ortega-Alonso; Markku Alén; Jaakko Kaprio; Jouko Karjalainen; Taina Rantanen; Urho M Kujala Journal: Ann Noninvasive Electrocardiol Date: 2009-10 Impact factor: 1.468
Authors: Ervin R Fox; Kathy L Klos; Alan D Penman; George J Blair; Benjamin D Blossom; Donna Arnett; Richard B Devereux; Tandaw Samdarshi; Eric Boerwinkle; Thomas H Mosley Journal: Am J Hypertens Date: 2010-05-06 Impact factor: 2.689
Authors: Anna E Hakalahti; Jari M Tapanainen; Juhani M Junttila; Kari S Kaikkonen; Heikki V Huikuri; Ulla E Petäjä-Repo Journal: Cardiovasc Diabetol Date: 2010-08-23 Impact factor: 9.951
Authors: Liyong Wang; Ashley Beecham; Marco R Di Tullio; Susan Slifer; Susan H Blanton; Tatjana Rundek; Ralph L Sacco Journal: BMC Med Genet Date: 2009-07-23 Impact factor: 2.103