Literature DB >> 12643617

Reciprocal variations of nNOS and HSP90 are associated with fasting in gastrointestinal tract of the piglet.

Jean-François Grongnet1, Jean-Claude David.   

Abstract

The effects of fasting on neuronal NO synthase (nNOS), Heme oxygenase 2 (HO-2), and heat shock protein 90 (HSP90) was determined by immunoblotting in the stomach, duodenum, mid-jejunum, distal ileum, and proximal colon of 28-day-old piglets. nNOS expression was drastically reduced in all the gastrointestinal areas studied while HO-2 was not changed. Concomitant with the nNOS decrease, elevated expressions of HSP90 were observed in these different areas. These results are discussed in terms of the regulation relationship between NOS and HSP90 and the possible protective effect of the heat shock protein and the potential application in digestive pathologies.

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Year:  2003        PMID： 12643617     DOI： 10.1023/a:1021948031333

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  37 in total

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Review 3.  The nitric oxide and cGMP signal transduction system: regulation and mechanism of action.

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Journal:  Biochim Biophys Acta       Date:  1993-08-18

4.  Heat-shock protein-73 protects against small intestinal warm ischemia-reperfusion injury in the rat.

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Authors:  X W Qu; H Wang; R A Rozenfeld; W Huang; W Hsueh
Journal:  Biochim Biophys Acta       Date:  1999-08-12

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Review 7.  Neural roles for heme oxygenase: contrasts to nitric oxide synthase.

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Authors:  C Van Ginneken; F Van Meir; S Sys; A Weyns
Journal:  Auton Neurosci       Date:  2001-08-13       Impact factor: 3.145

9.  hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

Authors:  Scott S Billecke; Andrew T Bender; Kimon C Kanelakis; Patrick J M Murphy; Ezra R Lowe; Yasuhiko Kamada; William B Pratt; Yoichi Osawa
Journal:  J Biol Chem       Date:  2002-03-28       Impact factor: 5.157

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Authors:  S Rattan; S Chakder
Journal:  Am J Physiol       Date:  1993-10
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  3 in total

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Authors:  Maria P Guarino; M Paula Macedo
Journal:  Br J Pharmacol       Date:  2006-04       Impact factor: 8.739

3.  MicroRNA transcriptome in swine small intestine during weaning stress.

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Journal:  PLoS One       Date:  2013-11-18       Impact factor: 3.240
  3 in total

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