Literature DB >> 12643593

Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells.

Su Bog Yee1, Jung Hwa Lee, Hae Young Chung, Kwang Sik Im, Song Ja Bae, Jae Soo Choi, Nam Deuk Kim.   

Abstract

We investigated the anti-proliferative effects of luteolin and apigenin, isolated from Ixeris sonchifolia Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cyde arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting data demonstrated that the down-regulated expression of CDK4 was correlated to the increase of p53 and CDK inhibitor p21(WAF1/CIP1) protein. These data suggest that luteolin may have potential as an anti-cancer agent.

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Year:  2003        PMID： 12643593     DOI： 10.1007/bf02976662

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  15 in total

1.  Isolation and identification of antimicrobial substances from Korean Lettuce (Youngia sonchifolia M.).

Authors:  Tae Yean Hwang; Chang Ki Huh
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Journal:  Pharm Res       Date:  2010-03-20       Impact factor: 4.200

3.  Antioxidant Activity and Inhibitory Effects of Black Rice Leaf on the Proliferation of Human Carcinoma Cells.

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Journal:  Biomed Res Int       Date:  2022-06-11       Impact factor: 3.246

4.  Plant flavone apigenin: An emerging anticancer agent.

Authors:  Eswar Shankar; Aditi Goel; Karishma Gupta; Sanjay Gupta
Journal:  Curr Pharmacol Rep       Date:  2017-10-14

5.  Antioxidative effect of luteolin pretreatment on simulated ischemia/reperfusion injury in cardiomyocyte and perfused rat heart.

Authors:  Rui-Qu Zhang; Dong-Ye Li; Tong-da Xu; Sha-Sha Zhu; Huan-Jun Pan; Fang Fang; Xin Wu; Hong Sun
Journal:  Chin J Integr Med       Date:  2016-03-08       Impact factor: 1.978

6.  The flavonoid luteolin induces nitric oxide production and arterial relaxation.

Authors:  Hongwei Si; Richard P Wyeth; Dongmin Liu
Journal:  Eur J Nutr       Date:  2013-04-21       Impact factor: 5.614

7.  Fabrication, in-vitro characterization, and enhanced in-vivo evaluation of carbopol-based nanoemulsion gel of apigenin for UV-induced skin carcinoma.

Authors:  Manmohan S Jangdey; Anshita Gupta; Swarnlata Saraf
Journal:  Drug Deliv       Date:  2017-11       Impact factor: 6.419

Review 8.  Cytotoxicity of dietary flavonoids on different human cancer types.

Authors:  Katrin Sak
Journal:  Pharmacogn Rev       Date:  2014-07

9.  Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer-Derived Cell Lines.

Authors:  Raquel P Souza; Patrícia de S Bonfim-Mendonça; Fabrícia Gimenes; Bianca A Ratti; Vanessa Kaplum; Marcos L Bruschi; Celso V Nakamura; Sueli O Silva; Silvya S Maria-Engler; Marcia E L Consolaro
Journal:  Oxid Med Cell Longev       Date:  2017-01-16       Impact factor: 6.543

10.  Digitoflavone inhibits IκBα kinase and enhances apoptosis induced by TNFα through downregulation of expression of nuclear factor κB-regulated gene products in human pancreatic cancer cells.

Authors:  Xueting Cai; Wuguang Lu; Yang Yang; Jie Yang; Juan Ye; Zhenhua Gu; Chunping Hu; Xiaoning Wang; Peng Cao
Journal:  PLoS One       Date:  2013-10-11       Impact factor: 3.240
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