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Literature DB >> 12642681

An introduction to pancreatic adenocarcinoma genetics, pathology and therapy.

Scott E Kern¹, Ralph H Hruban, Manuel Hidalgo, Charles J Yeo.

Abstract

Cancer is bad, but pancreatic cancer is especially so. Underlying the aggressive behavior of pancreatic cancer is a highly patterned set of biologic rules for its development. The accumulating discoveries regarding the genetic basis of pancreatic cancer and developments in the clinical management of the disease provide hope for meaningful improvements in the understanding and control of this disease.

Entities: Disease

Mesh：

Substances：
Biomarkers, Tumor

Year: 2002 PMID： 12642681 DOI： 10.4161/cbt.307

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.742

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Cited

19 in total

1. Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles.

Authors: Nariman V Amirkhanov; Kaijun Zhang; Mohan R Aruva; Mathew L Thakur; Eric Wickstrom
Journal: Bioconjug Chem Date: 2010-04-21 Impact factor: 4.774

2. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.

Authors: Sally E Dowen; Tatjana Crnogorac-Jurcevic; Rathi Gangeswaran; Mikkel Hansen; Jyrki J Eloranta; Vipul Bhakta; Teresa A Brentnall; Jutta Lüttges; Gunther Klöppel; Nick R Lemoine
Journal: Am J Pathol Date: 2005-01 Impact factor: 4.307

3. Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.

Authors: Shujie Zhao; Yubao Wang; Lin Cao; Michel M Ouellette; James W Freeman
Journal: Int J Cancer Date: 2010-11-01 Impact factor: 7.396

4. RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium.

Authors: Fikret Sahin; Wanglong Qiu; Robb E Wilentz; Christine A Iacobuzio-Donahue; Andres Grosmark; Gloria H Su
Journal: Pancreas Date: 2005-03 Impact factor: 3.327

Review 5. Target discovery and validation in pancreatic cancer.

Authors: Robert M Beaty; Mads Gronborg; Jonathan R Pollack; Anirban Maitra
Journal: Methods Mol Biol Date: 2007

6. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.

Authors: Erlinda E Embuscado; Daniel Laheru; Francesca Ricci; Ki Jung Yun; Sten de Boom Witzel; Allison Seigel; Katie Flickinger; Manuel Hidalgo; G Steven Bova; Christine A Iacobuzio-Donahue
Journal: Cancer Biol Ther Date: 2005-05-12 Impact factor: 4.742

An introduction to pancreatic adenocarcinoma genetics, pathology and therapy.

1. Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles.

2. Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.

3. Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.

4. RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium.

Review 5. Target discovery and validation in pancreatic cancer.

6. Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.

7. miR-301a as an NF-κB activator in pancreatic cancer cells.

8. Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.

9. Functional defects in the fanconi anemia pathway in pancreatic cancer cells.

10. RUNX3 expression in primary and metastatic pancreatic cancer.